Yan Qian, Yuan Zhaotong, Wu Yating, Zhou Chunmei, Dai Yihu, Wan Xiaoyue, Yang Dan, Liu Xu, Xue Nianhua, Zhu Yan, Yang Yanhui
Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China.
School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China.
Precis Chem. 2023 Jun 4;1(8):468-479. doi: 10.1021/prechem.3c00036. eCollection 2023 Oct 23.
Atomically precise water-soluble gold nanoclusters (Au NCs) protected by organic ligands have attracted growing attention in serving as unique nanomaterials with the potential to generate theranostic tools (bioimaging, biosensing, and biotherapy), due to their ultrasmall size, superior photoluminescence, good biocompatibility, and nontoxicity. More importantly, Au NCs afford a well-defined atomic packing structure and molecular purity, providing a superior platform to unravel the structure-performance correlations for biodistribution, biological pharmacokinetics, and excretion of Au NCs. In this Review, we mainly survey the synthesis of water-soluble Au NCs and the recent progress in biomedicine of Au NCs, including bioimaging, biosensing, and biotherapy. The effects of ligand and size on the biomedical properties are discussed in detail. We hope that the advances in this research area can expand the applications of Au NCs in biomedicine.
由有机配体保护的原子精确的水溶性金纳米团簇（Au NCs）作为具有产生治疗诊断工具（生物成像、生物传感和生物治疗）潜力的独特纳米材料，因其超小尺寸、优异的光致发光、良好的生物相容性和无毒性而受到越来越多的关注。更重要的是，Au NCs具有明确的原子堆积结构和分子纯度，为揭示Au NCs的生物分布、生物药代动力学和排泄的结构-性能关系提供了一个优越的平台。在本综述中，我们主要综述了水溶性Au NCs的合成以及Au NCs在生物医学方面的最新进展，包括生物成像、生物传感和生物治疗。详细讨论了配体和尺寸对生物医学性质的影响。我们希望这一研究领域的进展能够扩大Au NCs在生物医学中的应用。
