Animal Eye Guys of South Florida, Fort Lauderdale, FL.
Comparative Ocular Pathology Laboratory of Wisconsin (COPLOW), University of Wisconsin, Madison, WI.
Vet Ophthalmol. 2020 May;23(3):567-574. doi: 10.1111/vop.12753. Epub 2020 Feb 26.
To describe ocular clinical findings, gross/histopathologic findings, and treatment regimens in a series of migratory chuck-will's-widows (Antrostomus carolinensis) (CWW) with corneal epithelial defects.
Seven CWW were presented to the South Florida Wildlife Center (SFWC). Four presented with bilateral (OU) corneal ulceration; two developed corneal ulceration OU; one had no ocular lesions. Treatment protocols for patients with corneal ulcers included the following: medical therapy only or medical therapy combined with an additional procedure. Four patients including the bird with no ocular lesions were euthanized, and one patient died. Their globes were submitted for histopathology. Two patients were released.
Clinical findings prior to enucleation included superficial corneal ulceration with redundant epithelium persisting weeks to >1 month. On histopathology, epithelium in nonulcerated globes was remarkably thin; this was considered normal. Common histopathologic findings of ulcerated globes revealed epithelial and conjunctival attenuation with an acellular superficial stromal layer and hypercellular mid-stromal layer. One globe healed with medical therapy and cotton tip applicator debridement. Four globes healed by combination of medical therapy, equine amnion, nictitating membrane (NM) flap, and temporary tarsorrhaphy. No globes healed with diamond burr debridement or grid keratotomy.
Factors that may be contributing to these corneal epithelial defects include, but are not limited to, normally thin epithelium, exposure keratopathy, neurotrophic disease, epithelial turnover and inadequate stem cell recruitment, inherited/genetic causes, and unidentified infectious agents (eg, viral etiologies). Of the 12 eyes treated, one healed with medical therapy/cotton tip applicator debridement, and four healed with medical therapy/equine amnion/nictitating membrane flap/temporary tarsorrhaphy.
描述一系列迁徙的穴鸮（Antrostomus carolinensis）（CWW）中具有角膜上皮缺损的眼部临床发现、大体/组织病理学发现和治疗方案。
7 只穴鸮被送到南佛罗里达野生动物中心（SFWC）。其中 4 只出现双眼（OU）角膜溃疡；2 只发展为 OU 角膜溃疡；1 只无眼部病变。角膜溃疡患者的治疗方案包括以下内容：仅药物治疗或药物治疗联合附加程序。包括无眼部病变的鸟类在内的 4 只鸟被安乐死，1 只死亡。它们的眼球被提交进行组织病理学检查。2 只患者被释放。
在眼球摘除前的临床发现包括伴有持续数周至>1 个月的多余上皮的浅层角膜溃疡。在组织病理学上，未溃疡眼球的上皮明显变薄；这被认为是正常的。溃疡眼球的常见组织病理学发现包括上皮和结膜萎缩，伴有无细胞浅层基质层和富含细胞的中层基质层。一只眼球通过药物治疗和棉拭子清创术治愈。4 只眼球通过药物治疗、马羊膜、瞬膜（NM）瓣和临时睑裂缝合治愈。没有眼球通过钻石锉清创术或网格角膜切开术治愈。
导致这些角膜上皮缺损的因素包括但不限于正常薄的上皮、暴露性角膜病变、神经营养性疾病、上皮更新和干细胞募集不足、遗传/遗传原因以及未确定的感染因子（例如病毒病因）。在接受治疗的 12 只眼中，1 只用药物治疗/棉拭子清创术治愈，4 只用药物治疗/马羊膜/瞬膜瓣/临时睑裂缝合治愈。
