Morgan Francis L C, Moroni Lorenzo, Baker Matthew B
Department of Complex Tissue Regeneration, MERLN Institute, Maastricht University, 6200 MD, Maastricht, The Netherlands.
Adv Healthc Mater. 2020 Aug;9(15):e1901798. doi: 10.1002/adhm.201901798. Epub 2020 Feb 26.
The development of bioinks for bioprinting of cell-laden constructs remains a challenge for tissue engineering, despite vigorous investigation. Hydrogels to be used as bioinks must fulfill a demanding list of requirements, mainly focused around printability and cell function. Recent advances in the use of supramolecular and dynamic covalent chemistry (DCvC) provide paths forward to develop bioinks. These dynamic hydrogels enable tailorability, higher printing performance, and the creation of more life-like environments for ultimate tissue maturation. This review focuses on the exploration and benefits of dynamically cross-linked bioinks for bioprinting, highlighting recent advances, benefits, and challenges in this emerging area. By incorporating internal dynamics, many benefits can be imparted to the material, providing design elements for next generation bioinks.
尽管进行了大量研究，但用于生物打印含细胞构建体的生物墨水的开发仍然是组织工程面临的一项挑战。用作生物墨水的水凝胶必须满足一系列严格的要求，主要集中在可打印性和细胞功能方面。超分子和动态共价化学（DCvC）应用的最新进展为生物墨水的开发提供了前进的道路。这些动态水凝胶能够实现可定制性、更高的打印性能，并为最终的组织成熟创造更逼真的环境。本综述重点探讨了用于生物打印的动态交联生物墨水的探索和优势，突出了这一新兴领域的最新进展、优势和挑战。通过引入内部动力学，可以赋予材料许多优势，为下一代生物墨水提供设计元素。
