Tuftee Cody, Alsberg Eben, Ozbolat Ibrahim Tarik, Rizwan Muhammad
Department of Biomedical Engineering, Michigan Technological University, Houghton, MI, USA.
Jesse Brown Veterans Affairs Medical Center (JBVAMC), Chicago, IL 60612, USA; Department of Biomedical Engineering, University of Illinois at Chicago, Chicago, IL 60612, USA; Department of Orthopedic Surgery, University of Illinois at Chicago, Chicago, IL 60612, USA; Department of Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA; Department of Mechanical & Industrial Engineering, University of Illinois at Chicago, Chicago, IL 60612, USA; Jesse Brown Veterans Affairs Medical Center (JBVAMC) at Chicago, Chicago, IL 60612, USA.
Trends Biotechnol. 2024 Mar;42(3):339-352. doi: 10.1016/j.tibtech.2023.09.007. Epub 2023 Oct 16.
Advancements in 3D bioprinting have been hindered by the trade-off between printability and biological functionality. Existing bioinks struggle to meet both requirements simultaneously. However, new types of bioinks composed of densely packed microgels promise to address this challenge. These bioinks possess intrinsic porosity, allowing for cell growth, oxygen and nutrient transport, and better immunomodulatory properties, leading to superior biological functions. In this review, we highlight key trends in the development of these granular bioinks. Using examples, we demonstrate how granular bioinks overcome the trade-off between printability and cell function. Granular bioinks show promise in 3D bioprinting, yet understanding their unique structure-property-function relationships is crucial to fully leverage the transformative capabilities of these new types of bioinks in bioprinting.
3D生物打印的进展一直受到可打印性和生物功能之间权衡的阻碍。现有的生物墨水难以同时满足这两个要求。然而，由密集堆积的微凝胶组成的新型生物墨水有望应对这一挑战。这些生物墨水具有内在孔隙率，允许细胞生长、氧气和营养物质传输，并具有更好的免疫调节特性，从而带来卓越的生物功能。在这篇综述中，我们突出了这些颗粒状生物墨水开发的关键趋势。通过实例，我们展示了颗粒状生物墨水如何克服可打印性和细胞功能之间的权衡。颗粒状生物墨水在3D生物打印中显示出前景，但了解它们独特的结构-性能-功能关系对于充分利用这些新型生物墨水在生物打印中的变革能力至关重要。
