锰催化的炔丙基环己二烯酮与 TMSN 和 O 的自由基引发的串联转化为双环叠氮醇。
Mn-catalyzed radical initiated domino transformation of alkynylated cyclohexadienones with TMSN and O to bicyclic azido alcohols.
机构信息
Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India.
出版信息
Chem Commun (Camb). 2020 Mar 19;56(23):3453-3456. doi: 10.1039/d0cc00102c.
PMID:32101226
Abstract
An efficient Mn-catalyzed cascade azide radical addition/cyclization/oxygen insertion reaction of alkyne-tethered cyclohexadienones with TMSN3 under mild conditions is reported. This domino reaction presents good diastereoselectivity generating bicyclic azido alcohol scaffolds which can be transformed into useful building blocks in organic synthesis for medicinal chemistry.
摘要
报道了一种在温和条件下，Mn 催化的炔烃连接的环己二烯酮与 TMSN3 的串联叠氮自由基加成/环化/氧插入反应。该串联反应具有良好的非对映选择性，生成双环叠氮醇骨架，可转化为有机合成中药物化学的有用构建块。
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