Key Laboratory of Functional Small Organic Molecules, Ministry of Education, Jiangxi Normal University, 99 Ziyang Road, Nanchang 330022, China.
Org Biomol Chem. 2020 Nov 12;18(43):8908-8915. doi: 10.1039/d0ob01927e.
An efficient Cu and Mn co-mediated aerobic oxidative cyclization and azidation reaction of 1,3-enynes with amines and trimethylsilyl azide (TMSN3) for the synthesis of fully substituted azido pyrroles has been developed. The three-component reaction has the characteristics of high regioselectivity, wide substrate scope, and mild reaction conditions. A preliminary mechanism for this transformation is proposed.
一种高效的 Cu 和 Mn 共介导的有氧氧化环化和叠氮反应，用于 1,3-烯炔与胺和三甲基硅基叠氮化物（TMSN3）的合成，用于完全取代的叠氮基吡咯的合成。该三组分反应具有高区域选择性、广泛的底物范围和温和的反应条件的特点。提出了这种转化的初步机理。
