Department of Pathology, New York University School of Medicine, New York, NY 10016, USA; Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, NY 10016, USA.
Department of Pathology, New York University School of Medicine, New York, NY 10016, USA; Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, NY 10016, USA.
Trends Cancer. 2020 Mar;6(3):177-180. doi: 10.1016/j.trecan.2020.01.006. Epub 2020 Feb 7.
Mounting evidence links genetic lesions with genome topology alterations and aberrant gene activation. However, the role of epigenetic plasticity remains elusive. Emerging studies implicate DNA methylation, transcriptional elongation, long noncoding RNAs (lncRNAs), and CCCTC-binding factor (CTCF)-RNA interactions, but systematic approaches are needed to fully decipher the role of epigenetic plasticity in genome integrity and function.
越来越多的证据将遗传损伤与基因组拓扑结构改变和异常基因激活联系起来。然而，表观遗传可塑性的作用仍然难以捉摸。新兴研究表明 DNA 甲基化、转录延伸、长非编码 RNA（lncRNA）和 CCCTC 结合因子（CTCF）-RNA 相互作用，但需要系统的方法来充分阐明表观遗传可塑性在基因组完整性和功能中的作用。
