关于表观遗传可塑性和基因组拓扑结构。
On Epigenetic Plasticity and Genome Topology.
机构信息
Department of Pathology, New York University School of Medicine, New York, NY 10016, USA; Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, NY 10016, USA.
Department of Pathology, New York University School of Medicine, New York, NY 10016, USA; Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, NY 10016, USA.
出版信息
Trends Cancer. 2020 Mar;6(3):177-180. doi: 10.1016/j.trecan.2020.01.006. Epub 2020 Feb 7.
Abstract
Mounting evidence links genetic lesions with genome topology alterations and aberrant gene activation. However, the role of epigenetic plasticity remains elusive. Emerging studies implicate DNA methylation, transcriptional elongation, long noncoding RNAs (lncRNAs), and CCCTC-binding factor (CTCF)-RNA interactions, but systematic approaches are needed to fully decipher the role of epigenetic plasticity in genome integrity and function.
摘要
越来越多的证据将遗传损伤与基因组拓扑结构改变和异常基因激活联系起来。然而，表观遗传可塑性的作用仍然难以捉摸。新兴研究表明 DNA 甲基化、转录延伸、长非编码 RNA（lncRNA）和 CCCTC 结合因子（CTCF）-RNA 相互作用，但需要系统的方法来充分阐明表观遗传可塑性在基因组完整性和功能中的作用。
相似文献
1
On Epigenetic Plasticity and Genome Topology.关于表观遗传可塑性和基因组拓扑结构。
Trends Cancer. 2020 Mar;6(3):177-180. doi: 10.1016/j.trecan.2020.01.006. Epub 2020 Feb 7.
2
Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries.拓扑关联结构域（TAD）边界的分层显示，强边界对超级增强子具有优先绝缘作用。
Nat Commun. 2018 Feb 7;9(1):542. doi: 10.1038/s41467-018-03017-1.
3
CTCF-mediated genome organization and leukemogenesis.CTCF 介导的基因组组织与白血病发生。
Leukemia. 2020 Sep;34(9):2295-2304. doi: 10.1038/s41375-020-0906-x. Epub 2020 Jun 9.
4
EZH2 oncogenic mutations drive epigenetic, transcriptional, and structural changes within chromatin domains.EZH2 致癌突变驱动染色质域内的表观遗传、转录和结构变化。
Nat Genet. 2019 Mar;51(3):517-528. doi: 10.1038/s41588-018-0338-y. Epub 2019 Jan 28.
5
TAD disruption as oncogenic driver.TAD 破坏作为致癌驱动因素。
Curr Opin Genet Dev. 2016 Feb;36:34-40. doi: 10.1016/j.gde.2016.03.008. Epub 2016 Apr 22.
6
Emergence of the Noncoding Cancer Genome: A Target of Genetic and Epigenetic Alterations.非编码癌症基因组的出现：遗传和表观遗传改变的一个靶点
Cancer Discov. 2016 Nov;6(11):1215-1229. doi: 10.1158/2159-8290.CD-16-0745. Epub 2016 Oct 19.
7
Epigenetic maintenance of topological domains in the highly rearranged gibbon genome.拓扑结构域在高度重排的长臂猿基因组中的表观遗传维持。
Genome Res. 2018 Jul;28(7):983-997. doi: 10.1101/gr.233874.117. Epub 2018 Jun 18.
8
Chromatin-driven behavior of topologically associating domains.染色质驱动的拓扑关联域的行为。
J Mol Biol. 2015 Feb 13;427(3):608-25. doi: 10.1016/j.jmb.2014.09.013. Epub 2014 Oct 2.
9
Three-dimensional disorganization of the cancer genome occurs coincident with long-range genetic and epigenetic alterations.癌症基因组的三维无序与远距离遗传和表观遗传改变同时发生。
Genome Res. 2016 Jun;26(6):719-31. doi: 10.1101/gr.201517.115. Epub 2016 Apr 6.
10
Differential 3D chromatin organization and gene activity in genomic imprinting.基因组印迹中差异的 3D 染色质组织和基因活性。
Curr Opin Genet Dev. 2020 Apr;61:17-24. doi: 10.1016/j.gde.2020.03.004. Epub 2020 Apr 13.
引用本文的文献
1
FKBP5 intron 7 methylation is associated with higher anxiety proneness and smaller right thalamus volume in adolescents.FKBP5 内含子 7 甲基化与青少年更高的焦虑易感性和较小的右侧丘脑体积相关。
Brain Struct Funct. 2022 Nov;227(8):2809-2820. doi: 10.1007/s00429-022-02577-9. Epub 2022 Oct 5.
2
Epigenetics of Muscle- and Brain-Specific Expression of KLHL Family Genes.KLHL 家族基因在肌肉和大脑特异性表达中的表观遗传学
Int J Mol Sci. 2020 Nov 9;21(21):8394. doi: 10.3390/ijms21218394.
3
The Community Oncology and Academic Medical Center Alliance in the Age of Precision Medicine: Cancer Genetics and Genomics Considerations.精准医学时代的社区肿瘤学与学术医学中心联盟：癌症遗传学与基因组学考量
J Clin Med. 2020 Jul 6;9(7):2125. doi: 10.3390/jcm9072125.
本文引用的文献
1
RNA Interactions Are Essential for CTCF-Mediated Genome Organization.RNA 相互作用对于 CTCF 介导的基因组组织是必不可少的。
Mol Cell. 2019 Nov 7;76(3):412-422.e5. doi: 10.1016/j.molcel.2019.08.015. Epub 2019 Sep 12.
2
Distinct Classes of Chromatin Loops Revealed by Deletion of an RNA-Binding Region in CTCF.CTCF 中 RNA 结合区域缺失揭示了不同类别的染色质环。
Mol Cell. 2019 Nov 7;76(3):395-411.e13. doi: 10.1016/j.molcel.2019.07.039. Epub 2019 Sep 12.
3
Functional dissection of the Sox9-Kcnj2 locus identifies nonessential and instructive roles of TAD architecture.功能剖析 Sox9-Kcnj2 基因座揭示了 TAD 结构的非必要和指导作用。
Nat Genet. 2019 Aug;51(8):1263-1271. doi: 10.1038/s41588-019-0466-z. Epub 2019 Jul 29.
4
Highly rearranged chromosomes reveal uncoupling between genome topology and gene expression.高度重排的染色体揭示了基因组拓扑结构和基因表达之间的解耦。
Nat Genet. 2019 Aug;51(8):1272-1282. doi: 10.1038/s41588-019-0462-3. Epub 2019 Jul 15.
5
Dynamic enhancer partitioning instructs activation of a growth-related gene during exit from naïve pluripotency.动态增强子分区在退出幼稚多能性时指导与生长相关的基因的激活。
Elife. 2019 Apr 16;8:e44057. doi: 10.7554/eLife.44057.
6
Non-coding RNAs and chromatin domains.非编码 RNA 与染色质域。
Curr Opin Cell Biol. 2019 Jun;58:26-33. doi: 10.1016/j.ceb.2018.12.005. Epub 2019 Jan 23.
7
Transcription Elongation Can Affect Genome 3D Structure.转录延伸会影响基因组 3D 结构。
Cell. 2018 Sep 6;174(6):1522-1536.e22. doi: 10.1016/j.cell.2018.07.047. Epub 2018 Aug 23.
8
Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries.拓扑关联结构域（TAD）边界的分层显示，强边界对超级增强子具有优先绝缘作用。
Nat Commun. 2018 Feb 7;9(1):542. doi: 10.1038/s41467-018-03017-1.
9
A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies.一个 Myc 增强子簇调节正常和白血病造血干细胞层级。
Nature. 2018 Jan 25;553(7689):515-520. doi: 10.1038/nature25193. Epub 2018 Jan 17.
10
Cohesin Loss Eliminates All Loop Domains.黏连蛋白缺失消除了所有的环状结构域。
Cell. 2017 Oct 5;171(2):305-320.e24. doi: 10.1016/j.cell.2017.09.026.
Zotero 插件