Key Laboratory of Micro-nano Electronic Devices and Smart Systems of Zhejiang Province, College of Information Science & Electronic Engineering, Zhejiang University, Hangzhou 310027, People's Republic of China.
Nanotechnology. 2020 Apr 3;31(25):255204. doi: 10.1088/1361-6528/ab7a2c. Epub 2020 Feb 26.
The increased public concerns on healthcare, the environment and sustainable development inspired the development of biodegradable and biocompatible electronics that could be used as degradable electronics in implants. In this work, a fully biodegradable and flexible resistance random access memory (RRAM) was developed with low-cost biomaterial gelatin as the dielectric layer and the biodegradable polymer poly(lactide-coglycolide) acid (PLGA) as the substrate. PLGA can be synthesized by a simple solution process, and the PLGA substrate can be peeled off the handling substrate for operation once the devices are fabricated. The fabricated memory devices exhibited reliable nonvolatile resistive switching characteristics with a long retention time over 10 s and a near-constant on/off resistance ratio of 10 even after 200 bending cycles, showing the promising potential for application in flexible electronics. Degradation of the devices in deionized water and in phosphate buffered saline (PBS) solution showed that the whole devices can be completely degraded in water. The dissolution time of the metals and the gelatin layer was a few days, while that for PLGA is about 6 months, and can be modified by changing the synthesis conditions of the film, thus allowing the development of biodegradable electronics with designed dissolution time.
公众对医疗保健、环境和可持续发展的日益关注，激发了可生物降解和生物相容性电子产品的发展，这些电子产品可作为植入物中的可降解电子产品。在这项工作中，我们使用低成本生物材料明胶作为介电层，并使用可生物降解聚合物聚（丙交酯-乙交酯）酸（PLGA）作为基底，开发了全生物可降解和柔性的电阻式随机存取存储器（RRAM）。PLGA 可以通过简单的溶液工艺合成，并且一旦器件制造完成，PLGA 基底就可以从处理基底上剥离下来进行操作。所制造的存储器件表现出可靠的非易失性电阻开关特性，具有超过 10 s 的长保持时间，并且即使在 200 次弯曲循环后，导通/关断电阻比也接近恒定为 10，显示出在柔性电子领域应用的巨大潜力。在去离子水和磷酸盐缓冲盐水（PBS）溶液中的器件降解表明，整个器件可以在水中完全降解。金属和明胶层的溶解时间为数天，而 PLGA 的溶解时间约为 6 个月，并且可以通过改变薄膜的合成条件来进行修改，从而允许开发具有设计溶解时间的可生物降解电子产品。
