Department of Neurosurgery, Osaka International Cancer Institute.
Canon Medical Systems Corporation.
Magn Reson Med Sci. 2021 Mar 1;20(1):119-123. doi: 10.2463/mrms.bc.2019-0196. Epub 2020 Feb 27.
T-fluid-attenuated inversion recovery images (FLAIR) mismatch sign is now known to be a specific yet insensitive image feature for IDH-mutant, 1p19q non-codeleted astrocytoma. The current study revealed that lesion presenting T-FLAIR mismatch exhibited extremely long T- and T-relaxation time while T-FLAIR matched lesions showed low to moderate values. On the other hand, IDH-wildtype tumors presented noticeably short T- and T-relaxation time. These different relaxation time characteristics seemed to render T-FLAIR mismatch sign of becoming such a unique and specific image feature for IDH-mutant, 1p19q non-codeleted astrocytoma.
T 液衰减反转恢复(FLAIR)图像不匹配征象现已被认为是 IDH 突变、1p19q 非缺失型星形细胞瘤的一种特异性但不敏感的影像学特征。本研究显示,表现出 T-FLAIR 不匹配的病变呈现出极长的 T1 和 T2 弛豫时间,而 T-FLAIR 匹配的病变则表现出低到中度的值。另一方面,IDH 野生型肿瘤表现出明显较短的 T1 和 T2 弛豫时间。这些不同的弛豫时间特征似乎使 T-FLAIR 不匹配征象成为 IDH 突变、1p19q 非缺失型星形细胞瘤的一种独特而特异性的影像学特征。