From the Division of International Health (Public Health), Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Department of Parasitology, Graduate School of Medicine, Osaka City University, Osaka, Japan.
Pediatr Infect Dis J. 2020 Aug;39(8):678-683. doi: 10.1097/INF.0000000000002626.
We investigated the association between age, duration of clinical symptoms and viral shedding in outpatient children infected with respiratory syncytial virus (RSV) in Japan.
Outpatients younger than 2 years of age, with suspected RSV infection between 2014 and 2018, were enrolled in the study. Following informed consent, nasal samples were collected at first and second clinic visits (with 0-9 days gap). RSV-A or -B infection and viral load were determined by real-time polymerase chain reaction. Clinical symptoms were recorded at first clinic visit, and fever and symptoms were recorded at home for up to 8 days. Association between clinical symptoms and patient characteristics, such as age, sex and birth weight, were analyzed using ordered logistic regression analysis. The association between viral reduction and estimated shedding period was examined using linear regression analysis.
Among the 205 cases enrolled in the study, no difference was found in patient characteristics between RSV-A and -B infection. Duration of fever was prolonged with increased age. Duration of rhinorrhea and cough was shorter in females than in males and in groups with birth weight ≥3 kg than in those with <2.5 kg. Daily viral reduction increased and estimated viral elimination period decreased with age.
Fever duration was found to increase while viral shedding decreased with patient age.
我们研究了日本门诊儿童呼吸道合胞病毒（RSV）感染患者的年龄、临床症状持续时间与病毒脱落之间的关系。
本研究纳入了 2014 年至 2018 年期间年龄小于 2 岁、疑似 RSV 感染的门诊患者。在获得知情同意后，于首次和第二次就诊时（间隔 0-9 天）采集鼻拭子样本。采用实时聚合酶链反应检测 RSV-A 或 -B 感染和病毒载量。首次就诊时记录临床症状，在家中记录发热和症状长达 8 天。采用有序逻辑回归分析评估临床症状与患者特征（如年龄、性别和出生体重）之间的关系。采用线性回归分析评估病毒滴度下降与估计脱落期之间的关系。
本研究共纳入了 205 例患者，RSV-A 和 -B 感染患者的特征无差异。年龄越大，发热持续时间越长。女性发热时间短于男性，出生体重≥3kg 的患者发热时间短于出生体重<2.5kg 的患者。年龄越大，病毒每日下降量越大，估计病毒消除期越短。
随着患者年龄的增长，发热持续时间延长，病毒脱落减少。
