[肺癌循环肿瘤细胞侵袭和转移机制的研究进展]
[Research Advances in the Mechanism of Invasion and Metastasis of Circulating Tumor Cells in Lung Cancer].
作者信息
Mao Chunguo, Deng Bo
机构信息
Department of Thoracic Surgery, Daping Hospital, Army Medical University, Chongqing 400042, China.
出版信息
Zhongguo Fei Ai Za Zhi. 2020 Mar 20;23(3):189-195. doi: 10.3779/j.issn.1009-3419.2020.03.09. Epub 2020 Feb 27.
Abstract
In recent years, with the emergence of liquid biopsies, circulating tumor cells (CTCs) demonstrated significant value in the early diagnosis of patients with cancer, curative effect evaluation and prognosis evaluation. CTCs are the main cause of tumor metastasis, which indicates the poor prognosis of patients. Therefore, it is particularly important to elucidate the mechanism of CTC's generation, how to entry into circulatory system and immune escape. At present, accurate diagnosis and treatment has become an important direction to improve the prognosis of lung cancer patients. CTC for lung cancer is expected to provide a strong theoretical basis and important methods for accurate diagnosis and treatment of lung cancer. This paper reviews the latest research progress on the above hot issues.
摘要
近年来，随着液体活检的出现，循环肿瘤细胞（CTC）在癌症患者的早期诊断、疗效评估和预后评估中显示出重要价值。CTC是肿瘤转移的主要原因，这表明患者预后不良。因此，阐明CTC的产生机制、如何进入循环系统以及免疫逃逸机制尤为重要。目前，精准诊断与治疗已成为改善肺癌患者预后的重要方向。肺癌CTC有望为肺癌的精准诊断与治疗提供有力的理论依据和重要方法。本文综述了上述热点问题的最新研究进展。
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