School of Nutrition, University of Vienna, 1090 Vienna, Austria.
Health and Nutrition Specialist for UNICEF Regional Office for Europe and Central Asia, Almaty 050000, Kazakhstan.
Nutrients. 2020 Feb 24;12(2):590. doi: 10.3390/nu12020590.
The association between vitamin D status and inflammatory biomarkers and lipid profile is not well known, especially in adolescents. Therefore, the aim of the current study is to investigate the association of vitamin D status with serum lipids and inflammatory biomarkers, including IL-10, IL-6, hsCRP, and TNFR-2, in male adolescents.
A sample of seventy-one high school male students, aged 17 years old, from a high school in Tehran were enrolled in the study. They were divided into four groups including group with serum vitamin D below 25 (ng/mL) (SVD < 25; = 36), 25 and above (ng/mL) (SVD ≥ 25; = 35), negative-hsCRP ( = 48), and positive-hsCRP ( = 23). Weight, height, body mass index, dietary intake, serum lipids, and inflammatory biomarkers, including IL-10, IL-6, hsCRP, and TNFR-2, were measured.
In the (SVD < 25) group, the serum level of TNFR-2 was significantly higher compared to that in the (SVD ≥ 25) group. There was a significant negative association between serum TNFR-2 and vitamin D levels in the whole sample. We found significant lower levels of IL-10 in positive-hsCRP group compared to the negative-hsCRP group. In addition, there was a significant negative correlation between the serum vitamin D level and hsCRP in both hsCRP groups. The HDL level was lower in the (SVD < 25) group compared to that in the (SVD ≥ 25) group. Finally, there was a negative correlation between the serum HDL and hsCRP levels in the positive-hsCRP subjects.
Based on the findings it can be concluded that serum vitamin D affects HDL and inflammation status. Although serum levels of HDL and inflammation status are both predictors of metabolic syndrome and cardiovascular disease, further studies are needed to prove it, especially in adolescents.
维生素 D 状况与炎症生物标志物和血脂谱之间的关系尚不清楚，尤其是在青少年中。因此，本研究的目的是调查维生素 D 状况与血清脂质和炎症生物标志物（包括 IL-10、IL-6、hsCRP 和 TNFR-2）之间的关系，这些标志物在男性青少年中。
从德黑兰一所高中招募了 71 名 17 岁的高中生，他们被分为四组，包括血清维生素 D 低于 25（ng/ml）的组（SVD<25；n=36）、25 及以上（ng/ml）（SVD≥25；n=35）、hsCRP 阴性（n=48）和 hsCRP 阳性（n=23）。测量了体重、身高、体重指数、饮食摄入、血清脂质和炎症生物标志物，包括 IL-10、IL-6、hsCRP 和 TNFR-2。
在（SVD<25）组中，TNFR-2 血清水平明显高于（SVD≥25）组。整个样本中，血清 TNFR-2 与维生素 D 水平呈显著负相关。我们发现 hsCRP 阳性组的 IL-10 水平明显低于 hsCRP 阴性组。此外，在两个 hsCRP 组中，血清维生素 D 水平与 hsCRP 呈显著负相关。与（SVD≥25）组相比，（SVD<25）组的 HDL 水平较低。最后，在 hsCRP 阳性组中，血清 HDL 水平与 hsCRP 水平呈负相关。
根据研究结果，可以得出结论，血清维生素 D 影响 HDL 和炎症状态。尽管血清 HDL 和炎症状态水平都是代谢综合征和心血管疾病的预测因素，但还需要进一步的研究来证明这一点，尤其是在青少年中。
