血清 25-羟维生素 D 与 hsCRP 和其他新型炎症生物标志物在儿童中的相关性：一项横断面研究。

Associations of serum 25-hydroxyvitamin D with hsCRP and other novel inflammatory biomarkers in children: a cross-sectional study.

机构信息

Scientific Education Section, Affiliated Maternity & Child Health Care Hospital of Nantong University, Nantong, Jiangsu, China.

Department of Child Healthcare, Affiliated Maternity and Child Health Care Hospital of Nantong University, Nantong, Jiangsu, China.

出版信息

BMJ Open. 2024 Sep 5;14(9):e083227. doi: 10.1136/bmjopen-2023-083227.

DOI:10.1136/bmjopen-2023-083227

PMID:39242162

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11381719/

Abstract

OBJECTIVE

Previous studies have shown the anti-inflammatory effect of 25-hydroxyvitamin D (25(OH)D) and the crucial roles of high-sensitive C reactive protein (hsCRP) and novel inflammatory markers (red blood cell distribution width-platelet count ratio (RDWPCR), mean platelet volume-platelet count ratio (MPVPCR), neutrophil-lymphocyte ratio (NLR) and white blood cell-neutrophil ratios (WBCNR)) in several diseases, but scarce data explored the associations of 25(OH)D with hsCRP and novel inflammatory markers. This study aimed to investigate these associations in children.

DESIGN

Cross-sectional study.

SETTING

Children in China.

PARTICIPANTS

10141 children (mean age 14.6 months) were included.

PRIMARY AND SECONDARY OUTCOME MEASURES

HsCRP, red blood cell distribution width, platelet count, mean platelet volume, neutrophil, lymphocyte and white blood cell were measured.

RESULTS

Overall, serum 25(OH)D was inversely associated with hsCRP and novel inflammatory biomarkers. In multivariable analysis, serum 25(OH)D was inversely associated with hsCRP and novel inflammatory biomarkers (Q quartile (Q) 4 vs Q1: 1129.75 vs 2090.99 for hsCRP; 4246.94 vs 6829.89 for RDWPCR; 4863.57 vs 5545.66 for MPVPCR; 4345.76 vs 6507.46 for NLR; 2418.84 vs 2868.39 for WBCNR). Similar results also were observed in stratified analyses by sex (boys and girls). Moreover, serum 25(OH)D was inversely associated with elevated inflammation levels. After adjustment for other potential covariates, inverse associations between serum 25(OH)D and elevated inflammation levels were still observed. The corresponding ORs (95% CI) were 0.05 (0.04, 0.06) for hsCRP, 0.13 (0.11, 0.15) for RDWPCR, 0.74 (0.64, 0.85) for MPVPCR, 0.11 (0.09, 0.13) for NLR and 0.57 (0.49, 0.66) for WBCNR in the fourth quartile compared with the first quartile, respectively.

CONCLUSIONS

Generally, the graded and inverse associations of serum 25(OH)D with hsCRP and four novel inflammatory markers (RDWPCR, MPVPCR, NLR and WBCNR) were observed. The present study provided further support for the anti-inflammatory effects of 25(OH)D.

摘要

目的

先前的研究表明 25-羟维生素 D（25(OH)D）具有抗炎作用，高敏 C 反应蛋白（hsCRP）和新型炎症标志物（红细胞分布宽度-血小板计数比（RDWPCR）、平均血小板体积-血小板计数比（MPVPCR）、中性粒细胞-淋巴细胞比（NLR）和白细胞-中性粒细胞比（WBCNR））在几种疾病中起着关键作用，但关于 25(OH)D 与 hsCRP 和新型炎症标志物之间的关联的研究数据较少。本研究旨在探讨儿童中这些关联。

设计

横断面研究。

地点

中国的儿童。

参与者

纳入了 10141 名儿童（平均年龄 14.6 个月）。

主要和次要观察指标

hsCRP、红细胞分布宽度、血小板计数、平均血小板体积、中性粒细胞、淋巴细胞和白细胞。

结果

总体而言，血清 25(OH)D 与 hsCRP 和新型炎症生物标志物呈负相关。在多变量分析中，血清 25(OH)D 与 hsCRP 和新型炎症生物标志物呈负相关（四分位数（Q）4 与 Q1：hsCRP 为 1129.75 与 2090.99；RDWPCR 为 4246.94 与 6829.89；MPVPCR 为 4863.57 与 5545.66；NLR 为 4345.76 与 6507.46；WBCNR 为 2418.84 与 2868.39）。按性别（男孩和女孩）进行分层分析也得到了类似的结果。此外，血清 25(OH)D 与炎症水平升高呈负相关。在调整其他潜在混杂因素后，仍观察到血清 25(OH)D 与炎症水平升高之间的负相关。相应的 OR（95%CI）分别为 hsCRP 为 0.05（0.04，0.06），RDWPCR 为 0.13（0.11，0.15），MPVPCR 为 0.74（0.64，0.85），NLR 为 0.11（0.09，0.13），WBCNR 为 0.57（0.49，0.66），第四四分位数与第一四分位数相比。