Ayaki Masahiko, Negishi Kazuno, Yuki Kenya, Kawashima Motoko, Uchino Miki, Tsubota Kazuo
Otake Clinic Moon View Eye Center, Yamato 2420001, Japan.
Department of Ophthalmology, Keio University School of Medicine, Tokyo 1608582, Japan.
Diagnostics (Basel). 2020 Feb 24;10(2):124. doi: 10.3390/diagnostics10020124.
To evaluate seasonal variation in intraocular pressure (IOP) with and without short tear break-up time (SBUT, BUT ≤5 s) since dry eye and IOP are known to have seasonal variation.
This study enrolled 176 patients who visited one of six eye clinics, in Japan, four times for IOP measurement, in every season. The mean patient age was 67.9 years, including 79 males. Participants were divided into four groups based on the presence of glaucoma and/or SBUT and we compared the seasonal variation in IOP (winter and summer) among the four groups.
The IOP (mmHg) in winter and summer, respectively, was 12.8 ± 3.7 and 12.8 ± 3.1 for non-glaucoma patients without SBUT ( = 47, = 0.964), 14.8 ± 3.4 and 13.3 ± 3.4 for non-glaucoma patients with SBUT ( = 57, < 0.001), 14.3 ± 3.2 and 14.1 ± 3.4 for glaucoma patients without SBUT ( = 36, = 0.489), and 13.3 ± 3.0 and 11.6 ± 2.9 for glaucoma with SBUT ( = 36, < 0.001). Seasonal variation was largest across the seasons in the glaucoma with the SBUT group, and the magnitude of seasonal variation correlated with BUT (β = 0.228, = 0.003).
Seasonal variation tended to be larger in patients with SBUT than those without SBUT.
由于已知干眼和眼压（IOP）存在季节性变化，故评估有和无短泪膜破裂时间（SBUT，泪膜破裂时间≤5秒）情况下眼压的季节性变化。
本研究纳入了176名患者，他们在日本的六家眼科诊所之一就诊，每个季节进行4次眼压测量。患者平均年龄为67.9岁，其中男性79名。参与者根据青光眼和/或SBUT的情况分为四组，我们比较了四组之间眼压的季节性变化（冬季和夏季）。
无SBUT的非青光眼患者冬季和夏季的眼压（mmHg）分别为12.8±3.7和12.8±3.1（n = 47，P = 0.964），有SBUT的非青光眼患者为14.8±3.4和13.3±3.4（n = 57，P < 0.001），无SBUT的青光眼患者为14.3±3.2和14.1±3.4（n = 36，P = 0.489），有SBUT的青光眼患者为13.3±3.0和11.6±2.9（n = 36，P < 0.001）。在有SBUT的青光眼组中，季节性变化在各季节中最大，且季节性变化幅度与泪膜破裂时间相关（β = 0.228，P = 0.003）。
有SBUT的患者的季节性变化往往比无SBUT的患者更大。
