一氧化氮：重症监护中的新角色。
Nitric oxide: a new role in intensive care.
机构信息
Ulster Hospital, Dundonald, Belfast, Northern Ireland.
Department of Intensive Care, Royal Children's Hospital, Melbourne, VIC, Australia.
出版信息
Crit Care Resusc. 2020 Mar;22(1):72-79. doi: 10.51893/2020.1.sr1.
Abstract
Inhaled nitric oxide has been used for 30 years to improve oxygenation and decrease pulmonary vascular resistance. In the past 15 years, there has been increased understanding of the role of endogenous nitric oxide on cell surface receptors, mitochondria, and intracellular processes involving calcium and superoxide radicals. This has led to several animal and human experiments revealing a potential role for administered nitric oxide or nitric oxide donors in patients with systemic inflammatory response syndrome or ischaemia-reperfusion injury, and in patients for whom exposure of blood to artificial surfaces has occurred.
摘要
吸入一氧化氮已被用于改善氧合和降低肺血管阻力 30 年。在过去的 15 年中，人们对内源性一氧化氮在细胞表面受体、线粒体以及涉及钙和超氧自由基的细胞内过程中的作用有了更多的了解。这导致了一些动物和人体实验，揭示了给予一氧化氮或一氧化氮供体在全身炎症反应综合征或缺血再灌注损伤患者，以及在血液接触人工表面的患者中的潜在作用。
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