National 111 Center for Cellular Regulation and Molecular Pharmaceutics, Wuhan, Hubei, China; Department of Biomedicine and Biopharmacology, Hubei University of Technology, Wuhan, Hubei, China.
National 111 Center for Cellular Regulation and Molecular Pharmaceutics, Wuhan, Hubei, China; Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Free Radic Biol Med. 2021 Feb 1;163:153-162. doi: 10.1016/j.freeradbiomed.2020.12.008. Epub 2020 Dec 22.
Nitric oxide (NO) is a free radical playing an important pathophysiological role in cardiovascular and immune systems. Recent studies reported that NO levels were significantly lower in patients with COVID-19, which was suggested to be closely related to vascular dysfunction and immune inflammation among them. In this review, we examine the potential role of NO during SARS-CoV-2 infection from the perspective of the unique physical, chemical and biological properties and potential mechanisms of NO in COVID-19, as well as possible therapeutic strategies using inhaled NO. We also discuss the limits of NO treatment, and the future application of this approach in prevention and therapy of COVID-19.
一氧化氮（NO）是一种自由基，在心血管和免疫系统中发挥着重要的病理生理作用。最近的研究报告指出，COVID-19 患者的 NO 水平显著降低，这与其中的血管功能障碍和免疫炎症密切相关。在这篇综述中，我们从 NO 的独特物理、化学和生物学特性以及 COVID-19 中 NO 的潜在机制的角度，探讨了 NO 在 SARS-CoV-2 感染过程中的潜在作用，以及使用吸入一氧化氮的可能治疗策略。我们还讨论了 NO 治疗的局限性，以及这种方法在 COVID-19 预防和治疗中的未来应用。
