AFIPE Research Group, Faculty of Sciences for Physical Activity and Sport, INEF, Universidad Politécnica de Madrid (UPM), Madrid, Spain.
R. Samuel McLaughlin Foundation-Exercise and Pregnancy Laboratory, School of Kinesiology, The University of Western Ontario, London, Ontario, Canada.
Psychol Med. 2021 Mar;51(4):688-693. doi: 10.1017/S0033291719003714. Epub 2020 Feb 27.
Previous literature supports exercise as a preventative agent for prenatal depression; however, treatment effects for women at risk for prenatal depression remain unexplored. The purpose of the study was to examine whether exercise can lower depressive symptoms among women who began pregnancy at risk for depression using both a statistical significance and reliable and clinically significant change criteria.
This study is a secondary analysis of two randomized controlled trials that followed the same exercise protocol. Pregnant women were allocated to an exercise intervention group (IG) or control group (CG). All participants completed the Center for Epidemiological Depression (CES-D) scale at gestational week 9-16 and 36-38. Women with a baseline score ⩾16 were included. A clinically reliable cut-off was calculated as a 7-point change in scores from pre- to post-intervention.
Thirty-six women in the IG and 25 women in the CG scored ⩾16 on the CES-D at baseline. At week 36-38 the IG had a statistically significant lower CES-D score (14.4 ± 8.6) than the CG (19.4 ± 11.1; p < 0.05). Twenty-two women in the IG (61%) had a clinically reliable decrease in their post-intervention score compared to eight women in the CG (32%; p < 0.05). Among the women who met the reliable change criteria, 18 (81%) in the IG and 7 (88%) in the CG had a score <16 post-intervention, with no difference between groups (p > 0.05).
A structured exercise program might be a useful treatment option for women at risk for prenatal depression.
先前的文献支持运动是预防产前抑郁的一种手段；然而，对于有产前抑郁风险的女性，其治疗效果仍未得到探索。本研究旨在通过统计学意义和可靠且临床显著变化标准来检验运动是否可以降低有产前抑郁风险的女性的抑郁症状。
本研究是对两个遵循相同运动方案的随机对照试验的二次分析。孕妇被分配到运动干预组（IG）或对照组（CG）。所有参与者在妊娠 9-16 周和 36-38 周时完成了流行病学抑郁中心（CES-D）量表。以基线得分 ⩾16 的女性为研究对象。临床可靠的截定点被计算为从干预前到干预后的分数变化 7 分。
IG 组有 36 名女性和 CG 组有 25 名女性在 CES-D 上的基线得分 ⩾16。在第 36-38 周时，IG 的 CES-D 评分（14.4 ± 8.6）明显低于 CG（19.4 ± 11.1；p < 0.05）。IG 组有 22 名女性（61%）的干预后评分有临床可靠的下降，而 CG 组只有 8 名女性（32%）（p < 0.05）。在符合可靠变化标准的女性中，IG 组有 18 名（81%）和 CG 组有 7 名（88%）的女性在干预后得分 ⩽16，两组之间没有差异（p > 0.05）。
有组织的运动计划可能是有产前抑郁风险的女性的一种有用的治疗选择。
