Wei Yong, He Yu-Lan, Zheng Xue-Li
Department of Pathogen Biology, School of Public Health, Southern Medical University, Guangzhou 510515, China.
Yi Chuan. 2020 Feb 20;42(2):153-160. doi: 10.16288/j.yczz.19-262.
Mosquito-borne diseases have become an important public health issue of global concern because of their high incidence and transmission rate. As a vector for mosquito-borne diseases, studying the interaction mechanism between mosquitoes and mosquito-borne viruses will help control mosquito-borne diseases. The impaired innate immunity and immune barriers evasion caused by mosquito-borne viruses in mosquitoes pose a potential risk for the persistent infection of the virus in mosquitoes and the outbreak of mosquito-borne diseases. The RNA interference (RNAi) pathway, as a powerful antiviral defense barrier in mosquitoes, can inhibit viral replication and transmission by producing a variety of small RNAs to degrade viral RNA. In this review, we summarize the related studies on the innate immune mechanism against mosquito- borne virus infection in mosquitoes about small interfering RNA (siRNA), microRNA (miRNA), and Piwi-interacting RNA (piRNA), aiming to provide a theoretical reference for the prevention and control of mosquito-borne diseases.
蚊媒疾病因其高发病率和传播率已成为全球关注的重要公共卫生问题。作为蚊媒疾病的传播媒介，研究蚊子与蚊媒病毒之间的相互作用机制将有助于控制蚊媒疾病。蚊媒病毒在蚊子体内造成的先天免疫受损和免疫屏障逃避，对病毒在蚊子体内的持续感染和蚊媒疾病的爆发构成了潜在风险。RNA干扰（RNAi）途径作为蚊子体内强大的抗病毒防御屏障，可通过产生多种小RNA降解病毒RNA来抑制病毒复制和传播。在本综述中，我们总结了关于蚊子中针对蚊媒病毒感染的先天免疫机制的相关研究，涉及小干扰RNA（siRNA）、微小RNA（miRNA）和Piwi相互作用RNA（piRNA），旨在为蚊媒疾病的预防和控制提供理论参考。
