斯里兰卡阿努拉德普勒的 1114 名私立学校学生中，胃食管反流病相关症状的流行情况、相关因素和药物治疗。
Prevalence, associated factors and medication for symptoms related to gastroesophageal reflux disease among 1114 private-tuition students of Anuradhapura, Sri Lanka.
机构信息
Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Saliyapura, Anuradhapura, Sri Lanka.
Department of Pharmacology, Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Saliyapura, Anuradhapura, Sri Lanka.
出版信息
BMC Gastroenterol. 2020 Feb 27;20(1):45. doi: 10.1186/s12876-020-01193-3.
BACKGROUND
Gastroesophageal reflux disease (GORD) is a chronic and a common condition worldwide which causes mild to severe symptoms. Private tuition attendees are a group which could have potential risk factors for GORD. Therefore, we aimed to determine the prevalence, associated factors and medication for symptoms related to GORD among advanced level private-tuition attendees of Anuradhapura, Sri Lanka.
METHODS
A descriptive cross-sectional study was conducted among students aged ≥18 years. A self-administered questionnaire was used to collect data. Students scoring ≥ eight on the Frequency Scale for Symptoms of GORD were categorised to have symptoms related to GORD. Logistic regression was performed to determine the significant association between the variables of interest and the presence of symptoms related to GORD (P < 0.05).
RESULTS
Data of 1114 students were included for the analysis. A high prevalence of symptoms related to GORD (52% - 580/1114) was noted. Heartburn received the highest score among GORD symptoms. Biology students had the highest prevalence of GORD symptoms (63% - 127/201). Also, Biology students had the highest percentage for the utilisation of overall (17% - 35/201) and prescribed (13% - 27/201) medication for GORD symptoms. Presence of symptoms related to GORD was significantly associated with female sex [OR - 0.436 (95% CI 0.342-0.555)], being boarded [OR - 2.021 (95% CI 1.325-3.083)], chronic illness [OR - 2.632 (95% CI 1.439-4.813)], midnight snack [OR - 1.776 (95% CI 1.379-2.287)], frequent lack of breakfast [OR - 2.145 (95% CI 1.688, 2.725)], quick eating [OR - 1.394 (95% CI 1.091-1.780)] and inadequate sleep [OR - 2.077 (95% CI 1.624-2.655)].
CONCLUSION
A high prevalence of symptoms related to GORD in comparison to previous literature was found among private tuition attendees. Possible reasons for the above findings were discussed.
背景
胃食管反流病（GORD）是一种全球性的慢性常见疾病，可引起轻度至重度症状。辅导班学生是一组可能存在 GORD 潜在危险因素的群体。因此，我们旨在确定斯里兰卡阿努拉达普拉高级辅导班学生中与 GORD 相关症状的患病率、相关因素和药物治疗情况。
方法
对年龄≥18 岁的学生进行描述性横断面研究。使用自填式问卷收集数据。将 GORD 症状频率量表评分≥8 分的学生归类为存在与 GORD 相关的症状。采用逻辑回归确定感兴趣变量与存在与 GORD 相关症状之间的显著关联（P<0.05）。
结果
共纳入 1114 名学生进行分析。发现与 GORD 相关症状的患病率较高（52%-580/1114）。烧心在 GORD 症状中得分最高。生物专业的学生 GORD 症状的患病率最高（63%-127/201）。此外，生物专业的学生使用总体（17%-35/201）和处方（13%-27/201）药物治疗 GORD 症状的百分比最高。存在与 GORD 相关症状与女性[比值比（OR）-0.436（95%置信区间（CI）0.342-0.555）]、寄宿[OR-2.021（95%CI 1.325-3.083）]、慢性疾病[OR-2.632（95%CI 1.439-4.813）]、夜宵[OR-1.776（95%CI 1.379-2.287）]、经常不吃早餐[OR-2.145（95%CI 1.688-2.725）]、吃得过快[OR-1.394（95%CI 1.091-1.780）]和睡眠不足[OR-2.077（95%CI 1.624-2.655）]显著相关。
结论
与以往文献相比，辅导班学生中与 GORD 相关症状的患病率较高。对上述发现的可能原因进行了讨论。
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