Vora Rita V, Kota Rahul Krishna Suresh Kumar, Singhal Rochit R, Anjaneyan Gopikrishnan
Department of Skin and VD, Shree Krishna Hospital, Anand, Gujarat, India.
Department of Skin and VD, Amrita Institute of Medical Sciences, Kochi, Kerala, India.
Indian J Dermatol. 2019 Jan-Feb;64(1):19-22. doi: 10.4103/ijd.IJD_526_16.
Androgenic alopecia (AGA) is a hereditary androgen-dependent disorder, characterized by gradual conversion of terminal hair into miniaturized hair and defined by various patterns. Common age group affected is between 30 and 50 years. Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors that include diabetes and prediabetes, abdominal obesity, dyslipidemia, and hypertension. The relationship between androgenic alopecia and MetS is still poorly understood.
The aim was to study the clinical profile of androgenic alopecia and its association with cardiovascular risk factors.
This was a hospital-based cross-sectional study done on men in the age group of 25-40 years. Fifty clinically diagnosed cases with early-onset androgenic alopecia of Norwood Grade III or above and fifty controls without androgenic alopecia were included in the study. Data collected included anthropometric measurements, blood pressure, family history of androgenic alopecia, history of alcohol, smoking; fasting blood sugar, and lipid profile were done. MetS was diagnosed as per the new International Diabetes Federation criteria. Chi-square and Student's -test were used for statistical analysis.
MetS was seen in 5 (10%) cases and 1 (2%) control (=0.092). Abdominal obesity, hypertension, and lowered high-density lipoprotein were significantly higher in patients with androgenic alopecia when compared to that of the controls.
A higher prevalence of cardiovascular risk factors was seen in men with early-onset androgenic alopecia. Early screening for MetS and its components may be beneficial in patients with early-onset androgenic alopecia.
雄激素性脱发（AGA）是一种遗传性雄激素依赖型疾病，其特征是终毛逐渐转化为微小化毛发，并具有多种模式。受影响的常见年龄组在30至50岁之间。代谢综合征（MetS）是一组心血管危险因素，包括糖尿病和糖尿病前期、腹型肥胖、血脂异常和高血压。雄激素性脱发与代谢综合征之间的关系仍知之甚少。
旨在研究雄激素性脱发的临床特征及其与心血管危险因素的关联。
这是一项基于医院的横断面研究，针对25至40岁的男性。研究纳入了50例临床诊断为诺伍德III级及以上早发性雄激素性脱发的病例和50例无雄激素性脱发的对照。收集的数据包括人体测量、血压、雄激素性脱发家族史、饮酒史、吸烟史；进行空腹血糖和血脂谱检测。根据新的国际糖尿病联盟标准诊断代谢综合征。采用卡方检验和学生t检验进行统计分析。
5例（10%）病例和1例（2%）对照出现代谢综合征（P = 0.092）。与对照组相比，雄激素性脱发患者的腹型肥胖、高血压和高密度脂蛋白降低更为显著。
早发性雄激素性脱发男性中心血管危险因素的患病率较高。对早发性雄激素性脱发患者进行代谢综合征及其组分的早期筛查可能有益。
