Ha Yanxiang, Huang Po, Yan Yumeng, Xu Xiaolong, Li Bo, Guo Yuhong, Liu Qingquan
Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Institute of Traditional Chinese Medicine, Beijing 100010, China.
Beijing University of Chinese Medicine, Beijing 100029, China.
Evid Based Complement Alternat Med. 2020 Feb 12;2020:2803478. doi: 10.1155/2020/2803478. eCollection 2020.
Zong Qi depression is a disease recorded in the literature of Chinese traditional medicine for a long time. In recent years, the theory of Zong Qi depression has been more and more applied to the diagnosis and treatment of a variety of diseases. Astragalus is the most important drug used to treat the depression of Zong Qi. Meanwhile, Astragalus injection is also widely used in a variety of diseases in accordance with the manifestations of Zong Qi subsidence. However, there is a lack of systematic review or meta-analysis of the clinical effect of Astragalus injection in the treatment of Zong Qi subsidence. Therefore, we searched for diseases characterized by symptoms of Zong Qi subsidence (including heart failure, respiratory failure, acute respiratory distress syndrome, and acute lung injury) and evaluated the effect of Astragalus injection in these diseases with mortality and distance of a 6-minute walking test. The results showed that the mortality of patients with subsidence of Zong Qi decreased in 1 month (OR, 0.26 [0.12, 0.61], 95% CI, =0.002) and 1 year (OR, 0.38 [0.20, 0.69], 95% CI, =0.002) after using Astragalus injection. The distance of 6-minute walking test after 7 (MD, 91.60 [6.89, 176.31], 95% CI, =0.03), 14 (MD, 22.62 [13.80, 31.43], 95% CI, < 0.00001), and 28 days (MD, 108.31 [30.02, 186.59], 95% CI, =0.007) of using Astragalus injection also increased. Therefore, we believe that Astragalus injection has a certain therapeutic effect on the depression of Zong Qi.
宗气下陷是中医文献中记载已久的病症。近年来，宗气下陷理论越来越多地应用于多种疾病的诊疗。黄芪是治疗宗气下陷最重要的药物。同时，黄芪注射液也依据宗气下陷的表现被广泛用于多种疾病。然而，目前缺乏关于黄芪注射液治疗宗气下陷临床疗效的系统评价或Meta分析。因此，我们检索了以宗气下陷症状为特征的疾病（包括心力衰竭、呼吸衰竭、急性呼吸窘迫综合征和急性肺损伤），并以死亡率和6分钟步行试验距离评估黄芪注射液在这些疾病中的疗效。结果显示，使用黄芪注射液后1个月（OR，0.26[0.12，0.61]，95%CI，=0.002）和1年（OR，0.38[0.20，0.69]，95%CI，=0.002）宗气下陷患者的死亡率降低。使用黄芪注射液7天（MD，91.60[6.89，176.31]，95%CI，=0.03）、14天（MD，22.62[13.80，31.43]，95%CI，<0.00001）和28天（MD，108.31[30.02，186.59]，95%CI，=0.007）后的6分钟步行试验距离也增加。因此，我们认为黄芪注射液对宗气下陷有一定治疗作用。
