Feng Yan, Yang Chang, Yan Wen
Department of Pathology, Wuhan No. 1 Hospital, Wuhan, Hubei 430022, P.R. China.
Department of Respiratory Medicine, Hubei No.3 People's Hospital of Jianghan University, Wuhan, Hubei 430030, P.R. China.
Exp Ther Med. 2020 Mar;19(3):2211-2217. doi: 10.3892/etm.2020.8414. Epub 2020 Jan 3.
The purpose of this study was to explore the application value of lncRNA in lung cancer. From March 2017 to March 2019, 119 asthma patients and 125 healthy people undergoing physical examination in the same period were selected as the research objects. The levels of lncRNA in the peripheral blood of the two groups were compared, and the predictive value of for asthma as well as the differences in different inflammatory phenotypes were analyzed. The expression of was low in asthma patients (P<0.050), the diagnostic sensitivity and specificity for asthma were 79.83 and 66.40%, respectively (P<0.001), it was the lowest in mixed granulocytic asthma (P<0.050) and was negatively correlated with the course of disease (r=-0.666, P<0.001). Logistic regression analysis showed that course of disease, inflammatory phenotype and were independent factors affecting recurrence of asthma (P<0.050). was low expressed in asthma and had good predictive value for it; in mixed granulocytic asthma, its expression was the lowest and the course of disease was closely related. It might be the key to the diagnosis and treatment of asthma in the future.
本研究旨在探讨lncRNA在肺癌中的应用价值。选取2017年3月至2019年3月期间119例哮喘患者及同期125例进行体检的健康人作为研究对象。比较两组外周血中lncRNA水平，分析其对哮喘的预测价值以及不同炎症表型的差异。哮喘患者中lncRNA表达较低（P<0.050），对哮喘的诊断敏感性和特异性分别为79.83%和66.40%（P<0.001），在混合粒细胞性哮喘中最低（P<0.050），且与病程呈负相关（r=-0.666，P<0.001）。Logistic回归分析显示，病程、炎症表型及lncRNA是影响哮喘复发的独立因素（P<0.050）。lncRNA在哮喘中低表达，对哮喘具有良好的预测价值；在混合粒细胞性哮喘中其表达最低且与病程密切相关。它可能是未来哮喘诊断和治疗的关键。
