Qiao Xin, Hou Gang, He Yu-Lin, Song Dong-Fang, An Yi, Altawil Abdullah, Zhou Xiao-Ming, Wang Qiu-Yue, Kang Jian, Yin Yan
Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital of China Medical University, Shenyang, China.
Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.
Front Mol Biosci. 2022 Jun 13;9:927549. doi: 10.3389/fmolb.2022.927549. eCollection 2022.
Chronic inflammatory airway diseases, characterized by airway inflammation and airway remodelling, are increasing as a cause of morbidity and mortality for all age groups and races across the world. The underlying molecular mechanisms involved in chronic inflammatory airway diseases have not been fully explored. MicroRNAs (miRNAs) and long noncoding RNAs (lncRNAs) have recently attracted much attention for their roles in the regulation of a variety of biological processes. A number of studies have confirmed that both lncRNAs and miRNAs can regulate the initiation and progression of chronic airway diseases by targeting mRNAs and regulating different cellular processes, such as proliferation, apoptosis, inflammation, migration, and epithelial-mesenchymal transition (EMT). Recently, accumulative evidence has shown that the novel regulatory mechanism underlying the interaction among lncRNAs, miRNAs and messenger RNAs (mRNAs) plays a critical role in the pathophysiological processes of chronic inflammatory airway diseases. In this review, we comprehensively summarized the regulatory roles of the lncRNA-miRNA-mRNA network in different cell types and their potential roles as biomarkers, indicators of comorbidities or therapeutic targets for chronic inflammatory airway diseases, particularly chronic obstructive pulmonary disease (COPD) and asthma.
慢性炎症性气道疾病以气道炎症和气道重塑为特征，在全球所有年龄组和种族中，其作为发病和死亡原因的情况正在增加。慢性炎症性气道疾病所涉及的潜在分子机制尚未得到充分探索。微小RNA（miRNA）和长链非编码RNA（lncRNA）最近因其在多种生物学过程调控中的作用而备受关注。大量研究证实，lncRNA和miRNA均可通过靶向mRNA并调控不同细胞过程（如增殖、凋亡、炎症、迁移和上皮-间质转化（EMT））来调节慢性气道疾病的发生和发展。最近，越来越多的证据表明，lncRNA、miRNA和信使RNA（mRNA）之间相互作用的新型调控机制在慢性炎症性气道疾病的病理生理过程中起关键作用。在本综述中，我们全面总结了lncRNA-miRNA-mRNA网络在不同细胞类型中的调控作用及其作为慢性炎症性气道疾病（尤其是慢性阻塞性肺疾病（COPD）和哮喘）的生物标志物、合并症指标或治疗靶点的潜在作用。
