Yang Ivana V, Lozupone Catherine A, Schwartz David A
Department of Medicine, University of Colorado, School of Medicine, Aurora, Colo; National Jewish Health, Denver, Colo; Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, Colo.
Department of Medicine, University of Colorado, School of Medicine, Aurora, Colo.
J Allergy Clin Immunol. 2017 Jul;140(1):14-23. doi: 10.1016/j.jaci.2017.05.011.
Asthma prevalence has been on the increase, especially in North America compared with other continents. However, the prevalence of asthma differs worldwide, and in many countries the prevalence is stable or decreasing. This highlights the influence of environmental exposures, such as allergens, air pollution, and the environmental microbiome, on disease etiology and pathogenesis. The epigenome might provide the unifying mechanism that translates the influence of environmental exposures to changes in gene expression, respiratory epithelial function, and immune cell skewing that are hallmarks of asthma. In this review we will introduce the concept of the environmental epigenome in asthmatic patients, summarize previous publications of relevance to this field, and discuss future directions.
哮喘的患病率一直在上升，尤其是在北美洲，与其他各大洲相比更为明显。然而，哮喘的患病率在全球范围内存在差异，在许多国家，患病率保持稳定或呈下降趋势。这凸显了环境暴露因素，如过敏原、空气污染和环境微生物群，对疾病病因和发病机制的影响。表观基因组可能提供了一种统一的机制，将环境暴露的影响转化为基因表达、呼吸道上皮功能和免疫细胞偏向性的变化，而这些正是哮喘的特征。在本综述中，我们将介绍哮喘患者环境表观基因组的概念，总结该领域以往的相关出版物，并讨论未来的发展方向。
