Sun Yan, Xie Xinhui, Xu Yongxia, Wang Chen, Kong Xiaoming
Department of Geriatric Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China.
Laboratory of Brain Stimulation and Biological Psychiatry, The Second People's Hospital of Huizhou, Huizhou, Guangdong 516001, P.R. China.
Exp Ther Med. 2020 Mar;19(3):2303-2309. doi: 10.3892/etm.2020.8461. Epub 2020 Jan 17.
The present study investigated the relationship between hyperthyroidism and thyroid-associated ophthalmopathy by examining saccade dynamics to identify defects in eye tracking in patients with hyperthyroidism with no pre-existing eye damage and sensitive indicators that discriminated eye tracking ability in hyperthyroidism. A total of 33 outpatients with hyperthyroidism and 26 healthy controls participated in visually guided saccade (VGS) analysis. Patients with hyperthyroidism were divided into groups based on their medication status (medicated vs. unmedicated). Main sequence analysis was performed to identify differences in peak velocity and duration, and a general linear model (GLM) was used to identify differences in latency, peak acceleration and peak deceleration among the groups. The present study compared differences in the Spearman's correlation coefficient of the duration of saccades and the acceleration asymmetric index (R) among the groups. V values (V was the asymptotic value of the PV of saccades of large amplitude) were significantly different between the healthy control and unmedicated-hyperthyroidism groups. The results of the GLM-based analysis indicated no significant differences in saccade latency among the three groups. Peak acceleration was significantly different between the healthy control and unmedicated-hyperthyroidism groups (P<0.01). Peak deceleration was significantly different between the healthy control, unmedicated- and medicated-hyperthyroidism groups (P<0.01). R was significantly different between the healthy control and medicated-hyperthyroidism groups (P=0.004). The results of the present study suggested that patients with hyperthyroidism with no pre-existing eye damage exhibited significantly altered saccade dynamics during VGS. Therefore, R may be used as an indicator to monitor the level of eye movement coordination.
本研究通过检查眼球扫视动力学，以确定无既往眼损伤的甲状腺功能亢进症患者的眼动追踪缺陷以及区分甲状腺功能亢进症患者眼动追踪能力的敏感指标，从而研究甲状腺功能亢进症与甲状腺相关性眼病之间的关系。共有33例甲状腺功能亢进症门诊患者和26名健康对照者参与了视觉引导扫视（VGS）分析。甲状腺功能亢进症患者根据其用药状态（用药组与未用药组）进行分组。进行主序列分析以确定峰值速度和持续时间的差异，并使用一般线性模型（GLM）来确定各组之间在潜伏期、峰值加速度和峰值减速度方面的差异。本研究比较了各组之间扫视持续时间的Spearman相关系数和加速度不对称指数（R）的差异。健康对照组与未用药的甲状腺功能亢进症组之间的V值（V为大幅度扫视PV的渐近值）存在显著差异。基于GLM的分析结果表明，三组之间的扫视潜伏期无显著差异。健康对照组与未用药的甲状腺功能亢进症组之间的峰值加速度存在显著差异（P<0.01）。健康对照组、未用药和用药的甲状腺功能亢进症组之间的峰值减速度存在显著差异（P<0.01）。健康对照组与用药的甲状腺功能亢进症组之间的R存在显著差异（P=0.004）。本研究结果表明，无既往眼损伤的甲状腺功能亢进症患者在VGS期间表现出明显改变的扫视动力学。因此，R可作为监测眼动协调水平的指标。
