• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

基于三元共轭物的pH响应性10-羟基喜树碱前药纳米胶束递送系统的药代动力学

Pharmacokinetics of a ternary conjugate based pH-responsive 10-HCPT prodrug nano-micelle delivery system.

作者信息

Liu Yang, Li Juan, Li Zhi, Tang Xing, Zhang Zhenzhong

机构信息

School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.

School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, China.

出版信息

Asian J Pharm Sci. 2017 Nov;12(6):542-549. doi: 10.1016/j.ajps.2017.05.005. Epub 2017 May 23.

DOI:10.1016/j.ajps.2017.05.005
PMID:32104367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7032114/
Abstract

A pH-responsive conjugate based 10-hydroxycamptothecin-thiosemicarbazide-polyethene glycol 2000 (10-HCPT-hydro-PEG) nano-micelles were prepared in our previous study. In the present study, ultra-performance liquid chromatography (UPLC-MS) method is developed to investigate its pharmacokinetics and biodistribution in tumor bearing mice. The results demonstrated that the conjugate circulated for a much longer time in the blood circulation system than commercial 10-HCPT injection, and bioavailability was significantly improved compared with 10-HCPT. biodistribution study showed that the conjugate could enhance the targeting and residence time in tumor site.

摘要

在我们之前的研究中制备了一种基于pH响应性共轭物的10-羟基喜树碱-硫代氨基脲-聚乙二醇2000（10-HCPT-hydro-PEG）纳米胶束。在本研究中，开发了超高效液相色谱（UPLC-MS）方法来研究其在荷瘤小鼠体内的药代动力学和生物分布。结果表明，与市售10-HCPT注射液相比，该共轭物在血液循环系统中的循环时间长得多，并且与10-HCPT相比生物利用度显著提高。生物分布研究表明，该共轭物可以增强在肿瘤部位的靶向性和停留时间。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbc3/7032114/1a6c9ad7af2e/ajps443-fig-0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbc3/7032114/5df9f732c775/ajps443-ga-5001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbc3/7032114/a2f76515316d/ajps443-fig-0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbc3/7032114/e0960001a59c/ajps443-fig-0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbc3/7032114/bd5fada3ff50/ajps443-fig-0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbc3/7032114/fe13520ced48/ajps443-fig-0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbc3/7032114/ad50d6407a4a/ajps443-fig-0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbc3/7032114/4843a2734d12/ajps443-fig-0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbc3/7032114/1a6c9ad7af2e/ajps443-fig-0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbc3/7032114/5df9f732c775/ajps443-ga-5001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbc3/7032114/a2f76515316d/ajps443-fig-0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbc3/7032114/e0960001a59c/ajps443-fig-0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbc3/7032114/bd5fada3ff50/ajps443-fig-0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbc3/7032114/fe13520ced48/ajps443-fig-0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbc3/7032114/ad50d6407a4a/ajps443-fig-0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbc3/7032114/4843a2734d12/ajps443-fig-0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbc3/7032114/1a6c9ad7af2e/ajps443-fig-0007.jpg

相似文献

1
Pharmacokinetics of a ternary conjugate based pH-responsive 10-HCPT prodrug nano-micelle delivery system.基于三元共轭物的pH响应性10-羟基喜树碱前药纳米胶束递送系统的药代动力学
Asian J Pharm Sci. 2017 Nov;12(6):542-549. doi: 10.1016/j.ajps.2017.05.005. Epub 2017 May 23.
2
A pH-responsive prodrug delivery system of 10-HCPT for controlled release and tumor targeting.一种用于10-羟基喜树碱控释和肿瘤靶向的pH响应型前药递送系统。
Int J Nanomedicine. 2017 Mar 22;12:2227-2242. doi: 10.2147/IJN.S125849. eCollection 2017.
3
A polymeric micelle with an endosomal pH-sensitivity for intracellular delivery and enhanced antitumor efficacy of hydroxycamptothecin.具有内涵体 pH 敏感性的聚合物胶束用于细胞内递药和增强喜树碱的抗肿瘤疗效。
Acta Biomater. 2019 Apr 1;88:357-369. doi: 10.1016/j.actbio.2019.02.039. Epub 2019 Feb 26.
4
Novel anti-tumor strategy: PEG-hydroxycamptothecin conjugate loaded transferrin-PEG-nanoparticles.新型抗肿瘤策略：载聚乙二醇-羟基喜树碱的转铁蛋白-聚乙二醇-纳米粒子。
J Control Release. 2010 Jan 4;141(1):22-9. doi: 10.1016/j.jconrel.2009.08.024. Epub 2009 Sep 4.
5
Reduction-sensitive poly(ethylene glycol)-polypeptide conjugate micelles for highly efficient intracellular delivery and enhanced antitumor efficacy of hydroxycamptothecin.具有还原敏感性的聚乙二醇-多肽偶联胶束用于高效的细胞内递送和增强喜树碱的抗肿瘤疗效。
Nanotechnology. 2020 Apr 17;31(16):165102. doi: 10.1088/1361-6528/ab6749. Epub 2020 Jan 3.
6
Development and application of a UPLC-MS/MS method for the pharmacokinetic study of 10-hydroxy camptothecin and hydroxyethyl starch conjugate in rats.建立和应用 UPLC-MS/MS 法测定大鼠体内 10-羟基喜树碱与羟乙基淀粉接枝物的药代动力学。
J Pharm Biomed Anal. 2014 Jan;88:345-53. doi: 10.1016/j.jpba.2013.08.030. Epub 2013 Aug 31.
7
Responsive ZIF-90 nanocomposite material: targeted delivery of 10-hydroxycamptothecine to enhance the therapeutic effect of colon cancer (HCT116) cells.响应性ZIF-90纳米复合材料：10-羟基喜树碱的靶向递送以增强结肠癌（HCT116）细胞的治疗效果
RSC Med Chem. 2024 May 9;15(8):2663-2676. doi: 10.1039/d3md00725a. eCollection 2024 Aug 14.
8
Hydroxyethyl starch-10-hydroxy camptothecin conjugate: synthesis, pharmacokinetics, cytotoxicity and pharmacodynamics research.羟乙基淀粉-10-羟基喜树碱缀合物：合成、药代动力学、细胞毒性及药效学研究
Drug Deliv. 2016;23(1):277-84. doi: 10.3109/10717544.2014.911394. Epub 2015 Sep 10.
9
Mitochondrial-Targeted Triphenylphosphonium-Hydroxycamptothecin Conjugate and Its Nano-Formulations for Breast Cancer Therapy: In Vitro and In Vivo Investigation.线粒体靶向三苯基鏻-羟基喜树碱共轭物及其纳米制剂用于乳腺癌治疗的体内外研究
Pharmaceutics. 2023 Jan 24;15(2):388. doi: 10.3390/pharmaceutics15020388.
10
Preparation and and evaluations of 10-hydroxycamptothecin liposomes modified with stearyl glycyrrhetinate.硬脂酰基甘草次酸修饰的 10-羟基喜树碱脂质体的制备及评价。
Drug Deliv. 2019 Dec;26(1):673-679. doi: 10.1080/10717544.2019.1636422.

引用本文的文献

1
Advances in Antitumor Nano-Drug Delivery Systems of 10-Hydroxycamptothecin.10-羟基喜树碱抗肿瘤纳米给药系统的研究进展。
Int J Nanomedicine. 2022 Sep 14;17:4227-4259. doi: 10.2147/IJN.S377149. eCollection 2022.
2
Synthesis, characterization and evaluation of honokiol bisphosphate prodrugs protects against rats' brain ischemia-reperfusion injury.厚朴酚双磷酸酯前药的合成、表征及评价对大鼠脑缺血再灌注损伤具有保护作用。
Asian J Pharm Sci. 2019 Nov;14(6):640-648. doi: 10.1016/j.ajps.2018.11.004. Epub 2018 Dec 15.
3
A novel oral prodrug-targeting transporter MCT 1: 5-fluorouracil-dicarboxylate monoester conjugates.

本文引用的文献

1
A pH-responsive prodrug delivery system of 10-HCPT for controlled release and tumor targeting.一种用于10-羟基喜树碱控释和肿瘤靶向的pH响应型前药递送系统。
Int J Nanomedicine. 2017 Mar 22;12:2227-2242. doi: 10.2147/IJN.S125849. eCollection 2017.
2
Dual-targeting hybrid peptide-conjugated doxorubicin for drug resistance reversal in breast cancer.双重靶向杂合肽连接阿霉素逆转乳腺癌耐药。
Int J Pharm. 2016 Oct 15;512(1):1-13. doi: 10.1016/j.ijpharm.2016.08.016. Epub 2016 Aug 10.
3
A pH-sensitive hyaluronic acid prodrug modified with lactoferrin for glioma dual-targeted treatment.
一种新型的靶向转运体MCT 1的口服前药：5-氟尿嘧啶二羧酸单酯缀合物
Asian J Pharm Sci. 2019 Nov;14(6):631-639. doi: 10.1016/j.ajps.2019.04.001. Epub 2019 Apr 25.
4
Co-delivery of resveratrol and docetaxel via polymeric micelles to improve the treatment of drug-resistant tumors.通过聚合物胶束共递送白藜芦醇和多西他赛以改善耐药肿瘤的治疗。
Asian J Pharm Sci. 2019 Jan;14(1):78-85. doi: 10.1016/j.ajps.2018.03.002. Epub 2018 Mar 17.
5
Tissue Distribution and Anti-Lung Cancer Effect of 10-Hydroxycamptothecin Combined with Platycodonis Radix and Glycyrrhizae Radix ET Rhizoma.10-羟基喜树碱联合桔梗与甘草的体内组织分布及抗肺癌作用。
Molecules. 2019 May 30;24(11):2068. doi: 10.3390/molecules24112068.
6
Albumin binding, anticancer and antibacterial properties of synthesized zero valent iron nanoparticles.合成零价铁纳米粒子的白蛋白结合、抗癌和抗菌性能。
Int J Nanomedicine. 2018 Dec 28;14:243-256. doi: 10.2147/IJN.S188497. eCollection 2019.
一种用乳铁蛋白修饰的用于胶质瘤双靶点治疗的pH敏感型透明质酸前药。
Mater Sci Eng C Mater Biol Appl. 2016 Oct 1;67:159-169. doi: 10.1016/j.msec.2016.05.012. Epub 2016 May 6.
4
A safe, simple and efficient doxorubicin prodrug hybrid micelle for overcoming tumor multidrug resistance and targeting delivery.一种安全、简单、高效的阿霉素前药杂化胶束，用于克服肿瘤多药耐药性和靶向递药。
J Control Release. 2016 Aug 10;235:182-194. doi: 10.1016/j.jconrel.2016.06.003. Epub 2016 Jun 2.
5
NANOMEDICINE: will it offer possibilities to overcome multiple drug resistance in cancer?纳米医学：它会为克服癌症的多重耐药性提供可能性吗？
J Nanobiotechnology. 2016 Mar 9;14:17. doi: 10.1186/s12951-016-0172-2.
6
Delivering anti-cancer drugs with endosomal pH-sensitive anti-cancer liposomes.用内体 pH 敏感的抗癌脂质体输送抗癌药物。
Biomater Sci. 2016 Apr;4(4):627-38. doi: 10.1039/c5bm00479a. Epub 2016 Jan 25.
7
pH-responsive polymer-drug conjugates: Design and progress.pH 响应型聚合物-药物偶联物：设计与进展。
J Control Release. 2016 Jan 28;222:116-29. doi: 10.1016/j.jconrel.2015.12.024. Epub 2015 Dec 17.
8
pH-sensitive polymeric micelles formed by doxorubicin conjugated prodrugs for co-delivery of doxorubicin and paclitaxel.由阿霉素偶联前药形成的 pH 敏感聚合物胶束用于阿霉素和紫杉醇的共递送。
Carbohydr Polym. 2016 Feb 10;137:19-29. doi: 10.1016/j.carbpol.2015.10.050. Epub 2015 Oct 19.
9
A pH- and thermo-responsive poly(amino acid)-based drug delivery system.一种 pH 值和温度响应型聚（氨基酸）药物输送系统。
Colloids Surf B Biointerfaces. 2015 Dec 1;136:562-9. doi: 10.1016/j.colsurfb.2015.09.057. Epub 2015 Oct 1.
10
Pluronic-based functional polymeric mixed micelles for co-delivery of doxorubicin and paclitaxel to multidrug resistant tumor.基于普朗尼克的多功能聚合物混合胶束用于多药耐药肿瘤的阿霉素和紫杉醇共递送
Int J Pharm. 2015 Jul 5;488(1-2):44-58. doi: 10.1016/j.ijpharm.2015.04.048. Epub 2015 Apr 18.