Xu Meng, Mou Yanhua, Hu Mingming, Dong Wenxiang, Su Xitong, Wu Rongxia, Zhang Peng
School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.
Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.
Asian J Pharm Sci. 2018 Jul;13(4):373-382. doi: 10.1016/j.ajps.2018.05.004. Epub 2018 Jun 15.
The gelling hybrid hydrogel system has been reported to effectively concentrate chemotherapeutic drugs at the tumor site and sustain their release for a long period. DTX-micelles (docetaxel-loaded mixed micelles) are able to increase the solubility of DTX in water, and then a high drug loading rate of hydrogels can be achieved by encapsulating the docetaxel-loaded mixed micelles into the hydrogels. The thermosensitive nature of DTX-MM-hydrogels (thermosensitive hydrogels incorporated with docetaxel-loaded mixed micelles) can accelerate the formation of a depot of this drug-loaded system at the site of administration. Therefore, the hydrogels provide a much slower release compared with DTX-micelles and DTX-injection. An retention study has demonstrated that the DTX-MM-hydrogels can prolong the drug retention time and o trials have shown that the DTX-MM-hydrogels have a higher antitumor efficacy and systemic safety. In conclusion, the DTX-MM-hydrogels prepared in this study have considerable potential as a drug delivery system, with higher tumor inhibition effects and are less toxic to normal tissues.
据报道，凝胶化混合水凝胶系统能够有效地将化疗药物集中在肿瘤部位，并长时间持续释放。多西他赛胶束（负载多西他赛的混合胶束）能够增加多西他赛在水中的溶解度，然后通过将负载多西他赛的混合胶束包裹到水凝胶中，可以实现水凝胶的高载药率。多西他赛-胶束-水凝胶（包含负载多西他赛混合胶束的热敏水凝胶）的热敏特性可以加速这种载药系统在给药部位形成储库。因此，与多西他赛胶束和多西他赛注射剂相比，水凝胶的释放要慢得多。一项留存研究表明，多西他赛-胶束-水凝胶可以延长药物留存时间，并且试验表明多西他赛-胶束-水凝胶具有更高的抗肿瘤疗效和全身安全性。总之，本研究制备的多西他赛-胶束-水凝胶作为一种药物递送系统具有相当大的潜力，具有更高的肿瘤抑制作用，对正常组织的毒性较小。
