Marques Ana Camila, Costa Paulo Cardoso, Velho Sérgia, Amaral Maria Helena
UCIBIO-Applied Molecular Biosciences Unit, MEDTECH, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, R. Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.
Associate Laboratory i4HB-Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, R. Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.
Gels. 2023 Jul 24;9(7):593. doi: 10.3390/gels9070593.
The widespread push to invest in local cancer therapies comes from the need to overcome the limitations of systemic treatment options. In contrast to intravenous administration, local treatments using intratumoral or peritumoral injections are independent of tumor vasculature and allow high concentrations of therapeutic agents to reach the tumor site with minimal systemic toxicity. Injectable biodegradable hydrogels offer a clear advantage over other delivery systems because the former requires no surgical procedures and promotes drug retention at the tumor site. More precisely, in situ gelling systems based on poloxamers have garnered considerable attention due to their thermoresponsive behavior, biocompatibility, ease of preparation, and possible incorporation of different anticancer agents. Therefore, this review focuses on the use of injectable thermoresponsive hydrogels based on poloxamers and their physicochemical and biological characterization. It also includes a summary of these hydrogel applications in local cancer therapies using chemotherapy, phototherapy, immunotherapy, and gene therapy.
大力推动投资于局部癌症治疗源于克服全身治疗方案局限性的需求。与静脉给药不同，使用瘤内或瘤周注射的局部治疗不依赖肿瘤血管系统，并能使高浓度治疗剂以最小的全身毒性到达肿瘤部位。可注射的可生物降解水凝胶比其他给药系统具有明显优势，因为前者无需外科手术，且能促进药物在肿瘤部位的滞留。更确切地说，基于泊洛沙姆的原位凝胶系统因其热响应行为、生物相容性、易于制备以及可能掺入不同抗癌剂而备受关注。因此，本综述聚焦于基于泊洛沙姆的可注射热响应水凝胶的应用及其物理化学和生物学特性。它还总结了这些水凝胶在使用化疗、光疗、免疫疗法和基因疗法的局部癌症治疗中的应用。
