Zheng Xin, Feng Shuang, Wang Xiudan, Shi Zhenning, Mao Yuling, Zhao Qinfu, Wang Siling
Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
Asian J Pharm Sci. 2019 May;14(3):275-286. doi: 10.1016/j.ajps.2018.08.004. Epub 2018 Sep 20.
Mesoporous silica cocoon materials (MSNCs) and MgO doped mesoporous silica cocoons (MgO-MSNCs) with the cocoon-like hierarchical morphology and different alkalinities were synthesized as carriers for acidic drugs. Indomethacin (IMC) was selected as a model drug and loaded into carriers. All materials and the drug-loaded samples were characterized by nitrogen adsorption, FTIR spectroscopy, transmission electron microscopy (TEM), powder X-Ray diffraction (XRD) and differential scanning calorimetry (DSC). The effect of the Mg/Si molar ratio on the kinetics and equilibrium of IMC adsorption on MgO-MSNCs was thoroughly examined, and it was found that the increase in the Mg/Si molar ratio resulted in an increasing IMC adsorption rate due to the increased affinity between alkaline MgO-MSNCs and weak acid IMC. The adsorption kinetics fitted a pseudo second-order model well. The Freundlich isotherm showed a better fit, indicating that the coverage of IMC on the surface of MgO-MSNCs was heterogeneous. The maximum adsorption capacity of adsorbent was calculated by the Langmuir isotherm equation. The Temkin equation provided further support that the IMC adsorption on MgO-MSNCs was dominated by a chemisorption process. MgO-MSNCs also have the advantage of allowing an adjustment of the drug release rate of weak acid drug. The cytotoxicity assay indicated good biocompatibility of MgO-MSNCs. Our research on MgO-MSNCs carriers demonstrated their potential therapeutic benefit for safe and effective management of IMC adsorption and release.
合成了具有茧状分级形态和不同碱度的介孔二氧化硅茧材料（MSNCs）和氧化镁掺杂的介孔二氧化硅茧（MgO-MSNCs）作为酸性药物的载体。选择吲哚美辛（IMC）作为模型药物并负载到载体中。所有材料和载药样品通过氮气吸附、傅里叶变换红外光谱（FTIR）、透射电子显微镜（TEM）、粉末X射线衍射（XRD）和差示扫描量热法（DSC）进行表征。深入研究了Mg/Si摩尔比对IMC在MgO-MSNCs上吸附动力学和平衡的影响，发现Mg/Si摩尔比的增加导致IMC吸附速率增加，这是由于碱性MgO-MSNCs与弱酸IMC之间的亲和力增加。吸附动力学很好地拟合了伪二级模型。Freundlich等温线显示拟合效果更好，表明IMC在MgO-MSNCs表面的覆盖是不均匀的。通过Langmuir等温线方程计算吸附剂的最大吸附容量。Temkin方程进一步支持了IMC在MgO-MSNCs上的吸附以化学吸附过程为主。MgO-MSNCs还具有能够调节弱酸药物释放速率的优点。细胞毒性试验表明MgO-MSNCs具有良好的生物相容性。我们对MgO-MSNCs载体的研究证明了它们在安全有效地管理IMC吸附和释放方面的潜在治疗益处。
