National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University , Changchun 130117 Jilin, China.
Biomacromolecules. 2017 Aug 14;18(8):2306-2314. doi: 10.1021/acs.biomac.7b00464. Epub 2017 Jul 13.
The capacity to specifically destroy cancer cells while avoiding normal tissue is urgently desirable in cancer treatment. Herein, a photothermal-trigger-released system serves as a photoacoustic imaging agent constructed by entrapping diketopyrrolopyrrole-based conjugated polymers and curcumin in a poly(ethylene glycol) (PEG)-protected thermoresponsive liposomal phospholipid bilayer. This lipid nanostructure can improve the bioavailability of hydrophobic agents for photothermal treatment with high efficiency and deliver the anticancer drug curcumin to the tumor site actuated by near-infrared (NIR) irradiation. A significantly enhanced combined therapeutic effect to HepG2 tumor-bearing mice was acquired in contrast to the result of single therapy alone. These liposomes with the capability of photoacoustic imaging, greater EPR-induced accumulation in tumor sites, and hyperthermia ablation for photothermal chemotherapy show potential for photoacoustic imaging-guided photothermal/chemo combined therapeutic applications.
在癌症治疗中，迫切需要一种能够特异性地杀死癌细胞而不损伤正常组织的能力。在此，我们构建了一种光热触发释放系统，该系统由二酮吡咯并吡咯基共轭聚合物和姜黄素包封在聚乙二醇（PEG）保护的温敏脂质体磷脂双层中作为光声成像剂。这种脂质纳米结构可以提高光热治疗中疏水性药物的生物利用度，实现高效治疗，并在近红外（NIR）照射下将抗癌药物姜黄素递送到肿瘤部位。与单一治疗相比，荷 HepG2 肿瘤小鼠的联合治疗效果显著增强。这种具有光声成像能力、在肿瘤部位具有更高的 EPR 诱导积累和用于光热化疗的热消融能力的脂质体为光声成像引导的光热/化疗联合治疗应用提供了潜力。
