Shazam Hamda, Shaikh Fouzia, Hussain Zaheer
Department of Oral Pathology, Ziauddin College of Dentistry, Ziauddin University, Karachi, PAK.
Department of Pathology, Ziauddin University, Karachi, PAK.
Cureus. 2020 Jan 19;12(1):e6699. doi: 10.7759/cureus.6699.
Chronic periodontitis (CP) is a multifactorial oral inflammatory disease characterized by progressive destruction of bone and ultimate tooth loss. The alarming rise in the prevalence of periodontitis has led to the development of innovative diagnostic techniques. Several quantifiable biomarkers in the gingival crevicular fluid (GCF) and saliva of chronic periodontitis patients have been detected in the field of oral fluid diagnostics. Bone turnover biomarkers hold a valuable diagnostic potential in determining the extent of alveolar bone destruction and the risk of future bone loss. This review article highlights the importance of bone turnover markers in facilitating earlier detection, accurate diagnosis, and effective treatment strategies, leading to optimal clinical management of chronic periodontitis.
慢性牙周炎（CP）是一种多因素引起的口腔炎症性疾病，其特征是骨质进行性破坏并最终导致牙齿脱落。牙周炎患病率的惊人上升促使了创新诊断技术的发展。在口腔液体诊断领域，已在慢性牙周炎患者的龈沟液（GCF）和唾液中检测到几种可量化的生物标志物。骨转换生物标志物在确定牙槽骨破坏程度和未来骨质流失风险方面具有重要的诊断潜力。这篇综述文章强调了骨转换标志物在促进早期检测、准确诊断和有效治疗策略方面的重要性，从而实现慢性牙周炎的最佳临床管理。
