Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.
Department of Endocrinology and Metabolism, Wuxi Xishan People's Hospital, Wuxi, Jiangsu, China.
Biomed Res Int. 2020 Feb 11;2020:1751989. doi: 10.1155/2020/1751989. eCollection 2020.
Type 2 diabetes mellitus (T2DM) carries a high risk of hepatocellular carcinoma (HCC). Both serum fibroblast growth factor 19 (FGF19) and bile acid concentrations are associated with T2DM and HCC. We aimed at evaluating the relationships between FGF19 and bile acid concentrations and HCC in patients with T2DM.
Twenty-seven healthy volunteers (control group), 27 patients with T2DM (T2DM group), 16 patients with newly diagnosed HCC (HCC group), and 10 T2DM patients with newly diagnosed HCC (T2DM-HCC group) were studied at the Affiliated Hospital of Nantong University between June 2016 and June 2017. The serum concentrations of serum FGF19 and total bile acids (TBA) were measured in all the participants. Correlation analysis and multiple stepwise regression analysis of the FGF19 and TBA concentrations were performed in all the participants and in the four groups.
The concentrations of FGF19 were 220.5 pg/ml, 185.1 pg/ml, 115.8 pg/ml, and 70.4 pg/ml in the HCC, T2DM-HCC, control, and T2DM groups, respectively ( < 0.001), and the TBA concentrations were 21.75 mol/l, 14.25 mol/l, 14.25 mol/l, 14.25 mol/l, 14.25 < 0.001), and the TBA concentrations were 21.75 = 0.777; < 0.001), and the TBA concentrations were 21.75 = 0.777; < 0.001), and the TBA concentrations were 21.75 = 0.777; < 0.001), and the TBA concentrations were 21.75 = 0.777; < 0.001), and the TBA concentrations were 21.75 = 0.777; < 0.001), and the TBA concentrations were 21.75 .
Simultaneous increase of serum FGF19 and TBA levels may be used as indicators of HCC screening at early stage in patients with T2DM.
2 型糖尿病（T2DM）患者发生肝细胞癌（HCC）的风险较高。血清成纤维细胞生长因子 19（FGF19）和胆汁酸浓度均与 T2DM 和 HCC 相关。我们旨在评估 T2DM 患者中 FGF19 和胆汁酸浓度与 HCC 之间的关系。
2016 年 6 月至 2017 年 6 月，在南通大学附属医院研究了 27 名健康志愿者（对照组）、27 名 T2DM 患者（T2DM 组）、16 名新诊断 HCC 患者（HCC 组）和 10 名新诊断 T2DM-HCC 患者（T2DM-HCC 组）。所有参与者均测量血清 FGF19 和总胆汁酸（TBA）浓度。对所有参与者和四组进行 FGF19 和 TBA 浓度的相关分析和多元逐步回归分析。
HCC、T2DM-HCC、对照组和 T2DM 组的 FGF19 浓度分别为 220.5pg/ml、185.1pg/ml、115.8pg/ml 和 70.4pg/ml（<0.001），TBA 浓度分别为 21.75μmol/L、14.25μmol/L、14.25μmol/L、14.25μmol/L、14.25μmol/L（<0.001），FGF19 和 TBA 浓度呈正相关（r=0.777，P<0.001）。
T2DM 患者血清 FGF19 和 TBA 水平同时升高，可能作为 T2DM 患者早期 HCC 筛查的指标。
