近红外比率自组装治疗诊断纳米探针：癌症化疗的成像和跟踪。
Near-infrared ratiometric self-assembled theranostic nanoprobe: imaging and tracking cancer chemotherapy.
机构信息
Shaanxi Engineering Laboratory for Food Green Processing and safety Control, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710062, China.
出版信息
Chem Commun (Camb). 2020 Mar 26;56(25):3629-3632. doi: 10.1039/d0cc00416b.
We have developed a novel near-infrared ratiometric fluorescent theranostic nanoprobe. Upon reaction with glutathione, it releases a near-infrared fluorophore and chemotherapy drug. Notably, this nanoprobe can selectively kill HeLa and HepG-2 cancer cells over normal HUVEC cells with negligible side effects. Furthermore, this nanoprobe has been successfully applied to real-time fluorescence tracking and imaging cancer therapy in mice.
我们开发了一种新型的近红外比率荧光诊疗一体纳米探针。与谷胱甘肽反应后，它会释放出近红外荧光团和化疗药物。值得注意的是，这种纳米探针可以选择性地杀死 HeLa 和 HepG-2 癌细胞，而对正常 HUVEC 细胞几乎没有副作用。此外，该纳米探针已成功应用于实时荧光跟踪和小鼠癌症治疗的成像。
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