Shaanxi Engineering Laboratory for Food Green Processing and safety Control, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710062, China.
Chem Commun (Camb). 2020 Mar 26;56(25):3629-3632. doi: 10.1039/d0cc00416b.
We have developed a novel near-infrared ratiometric fluorescent theranostic nanoprobe. Upon reaction with glutathione, it releases a near-infrared fluorophore and chemotherapy drug. Notably, this nanoprobe can selectively kill HeLa and HepG-2 cancer cells over normal HUVEC cells with negligible side effects. Furthermore, this nanoprobe has been successfully applied to real-time fluorescence tracking and imaging cancer therapy in mice.
我们开发了一种新型的近红外比率荧光诊疗一体纳米探针。与谷胱甘肽反应后，它会释放出近红外荧光团和化疗药物。值得注意的是，这种纳米探针可以选择性地杀死 HeLa 和 HepG-2 癌细胞，而对正常 HUVEC 细胞几乎没有副作用。此外，该纳米探针已成功应用于实时荧光跟踪和小鼠癌症治疗的成像。
