Schlüter Torben, Ziyaei Halimehjani Azim, Wachtendorf Daniel, Schmidtmann Marc, Martens Jürgen
Institut of Chemistry, University of Oldenburg , Carl-von-Ossietzky-Strasse 9-11, 26129 Oldenburg, Germany.
Faculty of Chemistry, Kharazmi University , P.O. Box 15719-14911, 49 Mofateh Street, Tehran 31979-37551, Iran.
ACS Comb Sci. 2016 Aug 8;18(8):456-60. doi: 10.1021/acscombsci.6b00029. Epub 2016 Jul 12.
An efficient one-pot, four-component reaction for the synthesis of dithiocarbamates using carbon disulfide, cyclic imines, acid chlorides, and commercially available primary or secondary amines has been developed by performing an acid chloride addition to a heterocyclic imine followed by subsequent nucleophilic substitution of in situ generated dithiocarbamic acid. With the aid of the newly developed and powerful multicomponent reaction, a direct route for the synthesis of 24 unknown dithiocarbamates in moderate to good yield under mild conditions is enabled.
通过将酰氯加成到杂环亚胺上，随后对原位生成的二硫代氨基甲酸进行亲核取代，开发了一种高效的一锅四组分反应，用于使用二硫化碳、环状亚胺、酰氯和市售的伯胺或仲胺合成二硫代氨基甲酸盐。借助新开发的强大多组分反应，能够在温和条件下以中等至良好的产率直接合成24种未知的二硫代氨基甲酸盐。
