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阻止精子前进。

Stopping sperm in their tracks.

机构信息

Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, United States.

Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, United States.

出版信息

Elife. 2020 Feb 27;9:e55396. doi: 10.7554/eLife.55396.

DOI:10.7554/eLife.55396
PMID:32105216
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7046466/
Abstract

An automated high-throughput platform can screen for molecules that change the motility of sperm cells and their ability to fertilize.

摘要

一种自动化高通量平台可用于筛选能改变精子细胞运动能力及其受精能力的分子。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a6b/7046466/26e223ae0078/elife-55396-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a6b/7046466/26e223ae0078/elife-55396-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a6b/7046466/26e223ae0078/elife-55396-fig1.jpg

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Stopping sperm in their tracks.阻止精子前进。
Elife. 2020 Feb 27;9:e55396. doi: 10.7554/eLife.55396.
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Acrosome reaction of human sperm used for in vitro fertilization.用于体外受精的人类精子顶体反应。
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本文引用的文献

1
A phenotypic screening platform utilising human spermatozoa identifies compounds with contraceptive activity.一种利用人类精子进行表型筛选的平台,可识别具有避孕活性的化合物。
Elife. 2020 Jan 28;9:e51739. doi: 10.7554/eLife.51739.
2
Update on male hormonal contraception.男性激素避孕研究进展
Ther Adv Endocrinol Metab. 2019 Mar 14;10:2042018819834846. doi: 10.1177/2042018819834846. eCollection 2019.
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Global, regional, and subregional trends in unintended pregnancy and its outcomes from 1990 to 2014: estimates from a Bayesian hierarchical model.
全球、区域和次区域 1990 年至 2014 年意外妊娠及其结局趋势:来自贝叶斯层次模型的估计。
Lancet Glob Health. 2018 Apr;6(4):e380-e389. doi: 10.1016/S2214-109X(18)30029-9. Epub 2018 Mar 5.
4
Global, regional, and subregional classification of abortions by safety, 2010-14: estimates from a Bayesian hierarchical model.全球、区域和次区域不安全人工流产分类,2010-2014 年:贝叶斯层次模型估计。
Lancet. 2017 Nov 25;390(10110):2372-2381. doi: 10.1016/S0140-6736(17)31794-4. Epub 2017 Sep 27.
5
Investing in Family Planning: Key to Achieving the Sustainable Development Goals.计划生育投资:实现可持续发展目标的关键。
Glob Health Sci Pract. 2016 Jun 27;4(2):191-210. doi: 10.9745/GHSP-D-15-00374. Print 2016 Jun 20.
6
Role of disulfide linkage in action of bis(dialkylaminethiocarbonyl)disulfides as potent double-Edged microbicidal spermicide: Design, synthesis and biology.二硫键在双(二烷基氨基硫代羰基)二硫化物作为强效双刃剑型杀微生物杀精剂作用中的作用:设计、合成与生物学
Eur J Med Chem. 2016 Jun 10;115:275-90. doi: 10.1016/j.ejmech.2016.03.012. Epub 2016 Mar 9.
7
The story of the condom.避孕套的故事。
Indian J Urol. 2013 Jan;29(1):12-5. doi: 10.4103/0970-1591.109976.
8
History of oral contraception.口服避孕药史
Eur J Contracept Reprod Health Care. 2010 Dec;15 Suppl 2:S12-8. doi: 10.3109/13625187.2010.513071.
9
Update on male hormonal contraception: is the vasectomy in jeopardy?男性激素避孕更新:输精管切除术有风险吗?
Int J Impot Res. 2010 May-Jun;22(3):159-70. doi: 10.1038/ijir.2010.2. Epub 2010 Mar 25.
10
Platelet-activating factor significantly enhances intrauterine insemination pregnancy rates in non-male factor infertility.血小板活化因子显著提高非男性因素不孕症患者的宫腔内人工授精妊娠率。
Fertil Steril. 2004 Jul;82(1):52-6. doi: 10.1016/j.fertnstert.2003.11.057.