在一家性健康中心，淋病无症状接触者中淋病奈瑟菌阳性情况。

Neisseria gonorrhoeae positivity in clients presenting as asymptomatic contacts of gonorrhoea at a sexual health centre.

作者信息

Qian Sue, Foster Rosalind, Bourne Christopher, Vickers Tobias, McIver Ruthy, McNulty Anna

机构信息

Sydney Medical School, The University of Sydney, Camperdown, NSW 2006, Australia; and Corresponding author. Email:

Sydney Sexual Health Centre, PO Box 1614, Sydney, NSW 2001, Australia; and Kirby Institute, The University of New South Wales, Kensington, NSW 2052, Australia.

出版信息

Sex Health. 2020 Apr;17(2):187-191. doi: 10.1071/SH19091.

DOI:10.1071/SH19091

PMID:32105602

Abstract

UNLABELLED

Background Previous guidelines at the Sydney Sexual Health Centre (SSHC) recommended empirical antibiotic treatment for asymptomatic contacts of Neisseria gonorrhoeae at the time of testing. With increasing concerns around gonorrhoea antibiotic resistance, it has been suggested that asymptomatic contacts should only be treated based on test results.

METHODS

This retrospective study of data from the SSHC electronic medical record included a total of 295 gonorrhoea contacts from 1 January 2018 to 30 June 2018. The primary outcome was the proportion of asymptomatic gonorrhoea contacts with a positive gonorrhoea result from any anatomical site. Statistically significant differences in gonorrhoea positivity according to gender, sexual preference, use of PrEP, sex worker status, country of birth, preferred language and number of partners, were calculated using Fisher's exact test.

RESULTS

The overall proportion of asymptomatic gonorrhoea contacts with a positive gonorrhoea result was 27.1% (95% CI: 22.1-32.6%). The proportion of gonorrhoea positivity was significantly higher in females compared to males (52.0% vs 25.7%, P < 0.01), gay and bisexual men compared to heterosexual men (28.7% vs 0%, P < 0.01) and non-users of PrEP compared to PrEP users (31.2% vs 12.5%, P < 0.05). No statistically significant differences in gonorrhoea positivity were found in subgroups divided by sex worker status, country of birth, preferred language and number of partners.

CONCLUSION

The relatively low gonorrhoea positivity rate (27.1%) in asymptomatic gonorrhoea contacts at the SSHC between January and June 2018 supports guideline changes to no longer provide empirical antibiotic treatment to asymptomatic contacts.

摘要

未标注

背景悉尼性健康中心（SSHC）之前的指南建议在检测时对淋病奈瑟菌无症状接触者进行经验性抗生素治疗。随着对淋病抗生素耐药性的担忧日益增加，有人建议无症状接触者应仅根据检测结果进行治疗。

方法

这项对SSHC电子病历数据的回顾性研究纳入了2018年1月1日至2018年6月30日期间的295名淋病接触者。主要结局是任何解剖部位淋病检测结果呈阳性的无症状淋病接触者的比例。使用Fisher精确检验计算了根据性别、性取向、暴露前预防（PrEP）使用情况、性工作者身份、出生国家、首选语言和性伴侣数量划分的淋病阳性率的统计学显著差异。

结果

淋病检测结果呈阳性的无症状淋病接触者的总体比例为27.1%（95%置信区间：22.1 - 32.6%）。女性淋病阳性率显著高于男性（52.0%对25.7%，P < 0.01），男同性恋和双性恋男性高于异性恋男性（28.7%对0%，P < 0.01），未使用PrEP者高于PrEP使用者（31.2%对12.5%，P < 0.05）。按性工作者身份、出生国家、首选语言和性伴侣数量划分的亚组中，淋病阳性率未发现统计学显著差异。