Bromley T, Sundran D, Khaw C, Ratnayake M
<institution content-type="university">Adelaide Sexual Health Centre, Infectious Diseases Unit, Royal Adelaide Hospital</institution>, <city>Adelaide</city>, <state>SA</state> <postal-code>5000</postal-code>, <country>Australia</country>.
<institution content-type="university">School of Medicine, Faculty of Health Sciences, University of Adelaide</institution>, <city>Adelaide</city>, <state>SA</state> <postal-code>5000</postal-code>, <country>Australia</country>.
Sex Health. 2023 Dec;20(6):538-541. doi: 10.1071/SH22160.
Concerns regarding antimicrobial resistance and the appropriate use of antibiotics have resulted in many sexual health clinics moving away from the epidemiological treatment of contacts of gonorrhoea. The aim of this study was to inform decision-making regarding patients who are contacts who should be given epidemiological treatment.
This is a retrospective study of positivity rates of symptomatic and asymptomatic contacts of gonorrhoea who attended the Adelaide Sexual Health Centre from 1 January 2018 to 31 December 2019. Relevant demographic and behavioural characteristics were examined. Non-parametric continuous data were examined as medians and interquartile ranges, and categorical variables were examined as proportions and percentages. Chi-squared tests were used to determine any statistically significant differences in the proportions of participants testing positive to gonorrhoea based on the categorical variables.
A total of 402 clients were identified as contacts, of which 124 (30.8%) tested positive for gonorrhoea. Women were statistically more likely to test positive than men (27/56 (48.2%) of women vs 96/345 (27.8%) of men (P =0.002), 0/1 transgender female). From a total of 76 heterosexual men, 14 (18.4%) tested positive as contacts, compared to 82/269 (30.5%) of bisexual/MSM (P =0.038). Of the 214 asymptomatic bisexual/MSM, 55 (25.7%) were positive, 2/56 (3.6%) asymptomatic heterosexual men were positive and 10/29 (34.5%) asymptomatic females were positive for gonorrhoea.
This study identifies some demographic and behavioural characteristics that may be associated with a higher rate of gonorrhoea positivity as a contact, particularly females and MSM. Careful consideration may be required as to who should be given epidemiological treatment to ensure appropriate and judicious use of antibiotics.
对抗菌素耐药性以及抗生素合理使用的担忧,导致许多性健康诊所不再采用淋病接触者的流行病学治疗方法。本研究的目的是为关于哪些作为接触者的患者应接受流行病学治疗的决策提供依据。
这是一项回顾性研究,对2018年1月1日至2019年12月31日期间前往阿德莱德性健康中心的淋病有症状和无症状接触者的阳性率进行研究。检查了相关的人口统计学和行为特征。非参数连续数据以中位数和四分位数间距进行检查,分类变量以比例和百分比进行检查。卡方检验用于确定基于分类变量淋病检测呈阳性的参与者比例的任何统计学显著差异。
共识别出402名作为接触者的患者,其中124人(30.8%)淋病检测呈阳性。女性检测呈阳性的可能性在统计学上高于男性(女性27/56人(48.2%),男性96/345人(27.8%)(P =0.002),1名跨性别女性检测结果为阴性)。在76名异性恋男性中,14人(18.4%)作为接触者检测呈阳性,而双性恋/男男性行为者(bisexual/MSM)为82/269人(30.5%)(P =0.038)。在214名无症状双性恋/男男性行为者中,55人(25.7%)呈阳性,2/56名(3.6%)无症状异性恋男性呈阳性,10/29名(34.5%)无症状女性淋病检测呈阳性。
本研究确定了一些人口统计学和行为特征,这些特征可能与作为接触者淋病阳性率较高有关,特别是女性和男男性行为者。对于哪些人应接受流行病学治疗可能需要仔细考虑,以确保抗生素的适当和明智使用。