Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Hidaka, Saitama 350-1241, Japan.
Department of Systems Aging Science and Medicine, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo 173-0015, Japan.
Int J Mol Sci. 2020 Feb 25;21(5):1551. doi: 10.3390/ijms21051551.
Splicing of mRNA precursor (pre-mRNA) is a mechanism to generate multiple mRNA isoforms from a single pre-mRNA, and it plays an essential role in a variety of biological phenomena and diseases such as cancers. Previous studies have demonstrated that cancer-specific splicing events are involved in various aspects of cancers such as proliferation, migration and response to hormones, suggesting that splicing-targeting therapy can be promising as a new strategy for cancer treatment. In this review, we focus on the splicing regulation by RNA-binding proteins including Drosophila behavior/human splicing (DBHS) family proteins, serine/arginine-rich (SR) proteins and heterogeneous nuclear ribonucleoproteins (hnRNPs) in hormone-related cancers, such as breast and prostate cancers.
mRNA 前体（pre-mRNA）的剪接是一种从单个 pre-mRNA 生成多种 mRNA 异构体的机制，它在各种生物现象和疾病中起着至关重要的作用，如癌症。先前的研究表明，癌症特异性剪接事件涉及癌症的各个方面，如增殖、迁移和对激素的反应，这表明剪接靶向治疗可能是癌症治疗的一种有前途的新策略。在这篇综述中，我们重点介绍了 RNA 结合蛋白（包括果蝇行为/人类剪接（DBHS）家族蛋白、丝氨酸/精氨酸丰富（SR）蛋白和核不均一核糖核蛋白（hnRNPs））对激素相关癌症（如乳腺癌和前列腺癌）中的剪接调控。
