Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan.
The University of Melbourne, Parkville, VIC 3010, Australia.
Molecules. 2020 Feb 25;25(5):1035. doi: 10.3390/molecules25051035.
Natural compounds extracted from plants have gained immense importance in the fight against cancer cells due to their lesser toxicity and potential therapeutic effects. Raddeanin A (RA), an oleanane type triterpenoid is a major compound isolated from . As an anticancer agent, RA induces apoptosis, cell cycle arrest, inhibits invasion, migration and angiogenesis in malignant cell lines as well as in preclinical models. In this systemic review, the pharmacological effects of RA and its underlying molecular mechanisms were carefully analyzed and potential molecular targets have been highlighted. The apoptotic potential of RA can be mediated through the modulation of Bcl-2, Bax, caspase-3, caspase-8, caspase-9, cytochrome c and poly-ADP ribose polymerase (PARP) cleavage. PI3K/Akt signaling pathway serves as the major molecular target affected by RA. Furthermore, RA can block cell proliferation through inhibition of canonical Wnt/β-catenin signaling pathway in colorectal cancer cells. RA can also alter the activation of NF-κB and STAT3 signaling pathways to suppress invasion and metastasis. RA has also exhibited promising anticancer potential against drug resistant cancer cells and can enhance the anticancer effects of several chemotherapeutic agents. Overall, RA may function as a promising compound in combating cancer, although further in-depth study is required under clinical settings to validate its efficacy in cancer patients.
天然化合物从植物中提取出来，由于其毒性较小和潜在的治疗效果，在对抗癌细胞方面具有重要意义。雷迪苷 A（RA）是从 中分离得到的一种齐墩果烷型三萜类化合物。作为一种抗癌剂，RA 可诱导癌细胞系和临床前模型中的细胞凋亡、细胞周期停滞、抑制侵袭、迁移和血管生成。在这项系统评价中，仔细分析了 RA 的药理学作用及其潜在的分子机制，并强调了潜在的分子靶点。RA 的凋亡潜能可以通过调节 Bcl-2、Bax、caspase-3、caspase-8、caspase-9、细胞色素 c 和多聚 ADP 核糖聚合酶（PARP）切割来介导。PI3K/Akt 信号通路是受 RA 影响的主要分子靶点。此外，RA 可以通过抑制结直肠癌细胞中经典的 Wnt/β-catenin 信号通路来阻止细胞增殖。RA 还可以改变 NF-κB 和 STAT3 信号通路的激活，抑制侵袭和转移。RA 对耐药癌细胞也表现出有希望的抗癌潜力，并可以增强几种化疗药物的抗癌作用。总的来说，RA 可能是一种有前途的抗癌化合物，尽管需要在临床环境下进行进一步的深入研究，以验证其在癌症患者中的疗效。
