Center for Applied Research on Substance Use and Health Disparities, Nova Southeastern University , Miami, FL, USA.
J Psychoactive Drugs. 2020 Apr-Jun;52(2):172-175. doi: 10.1080/02791072.2020.1734695. Epub 2020 Feb 27.
Pregabalin is approved for the management of neuropathic pain, partial-onset seizures, and fibromyalgia. Although it is considered to have low potential for abuse, reports of misuse of pregabalin are emerging. The present study contributes to this literature by presenting preliminary evidence of pregabalin misuse. Mixed method interviews were conducted with prescription and/or illicit opioid (mis)users who reported a history of pregabalin misuse (N = 5). During semi-structured interviews, respondents provided descriptions of this practice, including motivation, route of administration, source, and drugs used/misused in combination with pregabalin. Motivations for pregabalin misuse included the self-treatment of physical pain (N = 1) and to achieve a desired psychoactive effect and/or combat opioid withdrawal symptoms (N = 4). Respondents described the misuse of pregabalin to potentiate the effects of heroin and cocaine, to feel "tipsy," and to experiment. We believe this report represents the first detailed contextual data about the misuse of pregabalin in the U.S. These misuse practices may represent an early indication of a growing problem. The recent permissibility of lower price generic versions has the potential to increase availability, decrease prices, and exacerbate pregabalin misuse.
普瑞巴林获批用于治疗神经病理性疼痛、部分发作性癫痫和纤维肌痛。虽然它被认为滥用潜力较低，但有关普瑞巴林滥用的报告正在出现。本研究通过提供普瑞巴林滥用的初步证据为该文献做出了贡献。研究对有处方和/或非法阿片类药物（滥用）使用史且报告有普瑞巴林滥用史的（N=5）患者进行了混合方法访谈。在半结构化访谈中，受访者提供了这种做法的描述，包括动机、给药途径、来源以及与普瑞巴林联合使用的药物。普瑞巴林滥用的动机包括治疗身体疼痛（N=1）和获得期望的精神活性作用和/或治疗阿片类药物戒断症状（N=4）。受访者描述了滥用普瑞巴林来增强海洛因和可卡因的效果、感觉“微醉”以及进行实验。我们认为该报告代表了美国普瑞巴林滥用的第一份详细背景数据。这些滥用行为可能代表了一个日益严重问题的早期迹象。最近允许较低价格的通用版本可能会增加可用性、降低价格并加剧普瑞巴林滥用。
