Division of Reproductive Endocrinology & Infertility, Department of Obstetrics & Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, California.
Fertil Steril. 2020 Feb;113(2):239-240. doi: 10.1016/j.fertnstert.2019.12.005.
Cryopreservation of reproductive tissues has recently reached an unprecedented level of efficiency. Whereas sperm cryopreservation had been successfully practiced for many years, until relatively recently, cryopreservation of embryos resulted in the loss of many potential implantations, when compared to fresh transfer. Embryo survival rates of approximately 80% with slow freezing methods were common, and the subsequent transfer of frozen-thawed embryos was associated with decreased implantation rates, despite good endometrial preparation techniques. The uptake of rapid freezing techniques, often called vitrification, has changed this calculus. New debates now address the question of whether all embryos should be cryopreserved, rather than simply those that cannot be safely transferred in a fresh cycle. The following series of review articles addresses the technology of cryobiology, the optimal preparation of the endometrium for cryopreserved embryo transfer, and the question of whether the presence of the corpus luteum at the time of embryo implantation may influence the subsequent development of hypertensive disorders of pregnancy.
生殖组织的冷冻保存最近达到了前所未有的效率水平。虽然精子冷冻保存已经成功实践了多年，但直到最近，与新鲜胚胎移植相比，胚胎冷冻保存导致许多潜在的胚胎着床失败。在缓慢冷冻方法下，胚胎存活率约为 80%是常见的，随后冷冻解冻胚胎的转移与着床率降低有关，尽管有良好的子宫内膜准备技术。快速冷冻技术的采用，通常称为玻璃化，改变了这种计算方法。现在新的争论涉及到是否应该冷冻保存所有胚胎，而不仅仅是那些在新鲜周期中不能安全转移的胚胎。以下一系列综述文章探讨了冷冻生物学技术、冷冻胚胎移植的最佳子宫内膜准备以及黄体在胚胎着床时的存在是否可能影响随后妊娠高血压疾病的发展等问题。
