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社会经济地位不利的黑人孕妇尿液中重金属浓度特征。

Characterization of urinary concentrations of heavy metals among socioeconomically disadvantaged black pregnant women.

机构信息

Department of Epidemiology, Human Genetics, and Environmental Sciences, UTHealth School of Public Health, Houston, TX, 77030, USA.

Southwest Center for Occupational and Environmental Health, Houston, TX, 77030, USA.

出版信息

Environ Monit Assess. 2020 Feb 27;192(3):200. doi: 10.1007/s10661-020-8163-z.

Abstract

The objective of this study was to characterize exposures to metals using biological samples collected on socioeconomically disadvantaged black pregnant women. We obtained 131 anonymous urine samples provided by black pregnant women visiting a Medicaid-serving prenatal clinic in Houston, TX, from March 27, 2017 to April 11, 2017. We analyzed urine samples for 15 metals including cadmium (Cd), arsenic (As), lead (Pb), and nickel (Ni) and for creatinine and cotinine. We found that median concentrations of zinc (Zn), selenium (Se), and aluminum (Al) among black pregnant women in this study were 1.5 to 3 times higher than levels reported among a cohort of well-educated non-Hispanic white pregnancy planners. We also observed elevated levels of urinary Cd and antimony (Sb) as compared with those reported for a nationally representative sample of adult women in the USA. Based on the results of an exploratory factor analysis, potential sources of metal exposures in this population may arise in home environments or be due to diet, industrial and natural sources, or traffic.

摘要

本研究旨在通过对社会经济地位低下的黑人孕妇采集的生物样本,对金属暴露情况进行特征描述。我们于 2017 年 3 月 27 日至 4 月 11 日,从德克萨斯州休斯顿市的一家接受医疗补助的产前诊所,获得了 131 份匿名的黑人孕妇尿液样本。我们对尿液样本进行了 15 种金属(包括镉(Cd)、砷(As)、铅(Pb)和镍(Ni))以及肌酸酐和可替宁的分析。我们发现,本研究中黑人孕妇的锌(Zn)、硒(Se)和铝(Al)中位数浓度比受过良好教育的非西班牙裔白人妊娠计划者队列中的报告值高 1.5 至 3 倍。与美国全国代表性成年女性样本相比,我们还观察到尿镉和锑(Sb)水平升高。基于探索性因子分析的结果,该人群中金属暴露的潜在来源可能来自家庭环境,也可能来自饮食、工业和自然来源或交通。

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