National Center for HTA, Istituto Superiore di Sanità, Via Giano della Bella 34, 00162, Rome, Italy.
St. Camillus International University of Health Sciences, Rome, Italy.
Pharmacoeconomics. 2020 May;38(5):473-484. doi: 10.1007/s40273-019-00879-1.
All health economics reviews on chronic and episodic migraine published to date underline the heterogeneity of results. Currently, the need for the generalizability of economic evaluations across different jurisdictions is considered a key issue to avoid unnecessary overlaps and to minimize the time to reimbursement decisions.
The aim of this study was to review the economic evaluations on the prophylaxis and treatments for migraine published in the previous 10 years (since 2009) and to perform a critical assessment of their generalizability.
We searched PubMed, EMBASE, and EconLit databases. Articles underwent a three-stage selection process. To assess the level of generalizability, we used the checklist implemented by Augustovski et al. Studies were classified as: (1) generalizable; (2) transferable; and (3) context specific.
In total, 227 articles were identified after running the search string and 11 studies were included in our review. Overall, none of the studies was judged as generalizable and three were judged transferable according to the established criteria.
Our review suggests that no evidence on the economic value of either acute or prophylactic treatments against migraine is generalizable to different jurisdictions. However, the majority of studies reporting results about prophylactic treatments were found to be transferable.
迄今为止，所有关于慢性和阵发性偏头痛的健康经济学综述都强调了结果的异质性。目前，普遍认为经济评估在不同司法管辖区具有通用性是一个关键问题，以避免不必要的重复，并最大限度地缩短报销决策的时间。
本研究旨在回顾过去 10 年（2009 年以来）发表的偏头痛预防和治疗的经济评估，并对其通用性进行批判性评估。
我们检索了 PubMed、EMBASE 和 EconLit 数据库。文章经过了三阶段的选择过程。为了评估通用性水平，我们使用了 Augustovski 等人实施的检查表。研究被分为：（1）通用；（2）可转移；和（3）具体情况。
经过搜索字符串的运行，共确定了 227 篇文章，其中 11 项研究纳入了我们的综述。总体而言，根据既定标准，没有一项研究被认为具有通用性，三项研究被认为具有可转移性。
我们的综述表明，针对偏头痛的急性或预防性治疗的经济价值没有证据可以推广到不同的司法管辖区。然而，报告预防性治疗结果的大多数研究被认为是可转移的。
