Ansaldi Mireille, Boulanger Pascale, Brives Charlotte, Debarbieux Laurent, Dufour Nicolas, Froissart Rémy, Gandon Sylvain, Le Hénaff Claire, Petit Marie-Agnès, Rocha Eduardo, Torres-Barceló Clara
Centre national de la recherche scientifique, Aix-Marseille Université, Institut de microbiologie de la Méditerranée, UMR7283, Laboratoire de chimie bactérienne, 31 chemin Joseph Aiguier, 13402 Marseille Cedex 9, France.
Université Paris-Sud, Université, Paris-Saclay, Institut de biologie intégrative de la cellule, UMR 9198 CEA, CNRS, Bât 430, Université Paris-Sud, 91405 Orsay cedex, France.
Virologie (Montrouge). 2020 Feb 1;24(1):9-22. doi: 10.1684/vir.2020.0809.
Bacteriophages have a prominent place in the living world. They participate to our understanding of the living world through three main aspects : (i) the dissection of the most intimist aspects of viral infection molecular mechanisms (molecular biology), (ii) the description and functioning mechanisms of ecosystems (ecology), and (iii) the adaptive dynamics of integrated viral and host-cell populations (evolution). This review looks back at the genesis of these fundamental findings and draws a picture of the most active fields of current research.
噬菌体在生物界中占据着显著地位。它们通过三个主要方面帮助我们理解生物界:(i)剖析病毒感染分子机制中最细微的方面(分子生物学),(ii)描述生态系统及其运作机制(生态学),以及(iii)病毒与宿主细胞群体整合后的适应性动态变化(进化)。本文回顾了这些重要发现的起源,并描绘了当前研究中最活跃的领域。