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使用迷幻药能否有益于冥想练习?探究个体、迷幻药及与冥想相关的因素。

Can Psychedelic Use Benefit Meditation Practice? Examining Individual, Psychedelic, and Meditation-Related Factors.

作者信息

Jiwani Zishan, Goldberg Simon B, Stroud Jack, Young Jacob, Curtin John, Dunne John D, Simonsson Otto, Webb Christian A, Carhart-Harris Robin, Schlosser Marco

机构信息

Department of Counseling Psychology, University of Wisconsin - Madison.

Center for Healthy Minds, University of Wisconsin - Madison.

出版信息

medRxiv. 2024 Aug 28:2024.08.27.24312677. doi: 10.1101/2024.08.27.24312677.

Abstract

INTRODUCTION

Meditation practice and psychedelic use have attracted increasing attention in the public sphere and scientific research. Both methods induce non-ordinary states of consciousness that may have significant therapeutic benefits. Thus, there is growing scientific interest in potential synergies between psychedelic use and meditation practice with some research suggesting that psychedelics may benefit meditation practice. The present study examined individual, psychedelic-related, and meditation-related factors to determine under what conditions meditators perceive psychedelic use as beneficial for their meditation practice.

METHOD

Participants ( = 863) who had reported psychedelic use and a regular meditation practice (at least 3 times per week during the last 12 months) were included in the study. To accommodate a large number of variables, machine learning (i.e., elastic net, random forest) was used to analyze the data.

RESULTS

Most participants ( = 634, 73.5%) found psychedelic use to have a positive influence on their quality of meditation. Twenty-eight variables showed significant zero-order associations with perceived benefits even following a correction. Elastic net had the best performance (R = .266) and was used to identify the most important features. Across 53 variables, the model found that greater use of psychedelics, intention setting during psychedelic use, agreeableness, and exposure to N,N-Dimethyltryptamine (N,N-DMT) were most likely to be associated with the perception that psychedelics benefit meditation practice. The results were consistent across several different approaches used to identify the most important variables (i.e., Shapley values, feature ablation).

DISCUSSION

Results suggest that most meditators found psychedelic use to have a positive influence on their meditation practice, with: 1) regularity of psychedelic use, 2) the setting of intentions for psychedelic use, 3) having an agreeable personality, and 4) reported use of N,N-DMT being the most likely predictors of perceiving psychedelic use as beneficial. Longitudinal designs and randomized trials manipulating psychedelic use are needed to establish causality.

摘要

引言

冥想练习和迷幻剂的使用在公共领域和科学研究中越来越受到关注。这两种方法都会诱导出可能具有显著治疗益处的非普通意识状态。因此,科学界对迷幻剂使用与冥想练习之间的潜在协同作用越来越感兴趣,一些研究表明迷幻剂可能有益于冥想练习。本研究考察了个体、与迷幻剂相关以及与冥想相关的因素,以确定在何种条件下冥想者认为使用迷幻剂对其冥想练习有益。

方法

本研究纳入了报告使用过迷幻剂且有规律冥想练习(在过去12个月中每周至少3次)的参与者(n = 863)。为了处理大量变量,使用机器学习(即弹性网络、随机森林)来分析数据。

结果

大多数参与者(n = 634,73.5%)发现使用迷幻剂对其冥想质量有积极影响。即使经过校正,仍有28个变量与感知到的益处呈现显著的零阶关联。弹性网络表现最佳(R = 0.266),并被用于识别最重要的特征。在53个变量中,该模型发现更多地使用迷幻剂、迷幻剂使用期间设定意图、宜人性以及接触N,N-二甲基色胺(N,N-DMT)最有可能与认为迷幻剂有益于冥想练习的认知相关。在用于识别最重要变量的几种不同方法(即夏普利值、特征消融)中,结果是一致的。

讨论

结果表明,大多数冥想者发现使用迷幻剂对其冥想练习有积极影响,其中:1)迷幻剂使用的规律性,2)迷幻剂使用意图的设定,3)具有宜人性的性格,4)报告使用N,N-DMT是最有可能预测认为使用迷幻剂有益的因素。需要纵向设计和操纵迷幻剂使用的随机试验来确定因果关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aae5/11383514/70b6d53cef44/nihpp-2024.08.27.24312677v1-f0001.jpg

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