奥硝唑：一种用于治疗阴道毛滴虫感染的新型抗原虫化合物。
Ornidazole: a new antiprotozoal compound for treatment of Trichomonas vaginalis infection.
作者信息
Sköld M, Gnarpe H, Hillström L
出版信息
Br J Vener Dis. 1977 Feb;53(1):44-8. doi: 10.1136/sti.53.1.44.
Abstract
A new anti-protozoal compound, ornidazole, a derivative of nitroimidazole, was given in a single 2 g dose to 20 women with Trichomonas vaginalis infection. All the women were cured, but they suffered some side-effects. Plasma levels of ornidazole reached a peak five to eight times higher than minimum inhibitory concentrations and exceeded this level for at least 36 hours. It is therefore possible that a smaller dose might have had an adequate trichomonicidal effect and fewer side-effects. Further studies are in progress.
摘要
一种新型抗寄生虫化合物奥硝唑，是硝基咪唑的衍生物，以单次2克剂量给予20名阴道毛滴虫感染的女性。所有女性均被治愈，但出现了一些副作用。奥硝唑的血浆水平达到的峰值比最低抑菌浓度高五至八倍，并至少在36小时内超过该水平。因此，较小剂量可能具有足够的杀滴虫效果且副作用较少。进一步的研究正在进行中。
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Ornidazole: a new antiprotozoal compound for treatment of Trichomonas vaginalis infection.奥硝唑：一种用于治疗阴道毛滴虫感染的新型抗原虫化合物。
Br J Vener Dis. 1977 Feb;53(1):44-8. doi: 10.1136/sti.53.1.44.
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Br J Vener Dis. 1977 Jun;53(3):193-4. doi: 10.1136/sti.53.3.193.
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[Short-term treatment of trichomoniasis].
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[Single-dose treatment with ornidazole (Tiberal) in vaginal trichomoniasis. A controlled clinical study in general practice].[奥硝唑（替硝唑）单剂量治疗阴道滴虫病。全科医疗中的一项对照临床研究]
Ugeskr Laeger. 1978 Jun 19;140(25):1485-7.
引用本文的文献
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Chlorinated metronidazole as a promising alternative for treating trichomoniasis.氯化甲硝唑作为治疗滴虫病的一种有前景的替代药物。
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Plasma levels after a single oral dose of 1.5 g ornidazole.单次口服1.5克奥硝唑后的血浆水平。
Br J Vener Dis. 1977 Aug;53(4):236-9. doi: 10.1136/sti.53.4.236.
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Comparative susceptibilities of anaerobic bacteria to metronidazole, ornidazole, and SC-28538.厌氧菌对甲硝唑、奥硝唑和SC-28538的敏感性比较
Antimicrob Agents Chemother. 1978 Oct;14(4):609-13. doi: 10.1128/AAC.14.4.609.
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The nitroimidazole family of drugs.硝基咪唑类药物家族。
Br J Vener Dis. 1978 Apr;54(2):69-71.
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How suitable are available pharmaceuticals for the treatment of sexually transmitted diseases? 1: Conditions presenting as genital discharges.现有药物对性传播疾病的治疗适用性如何？1：表现为生殖器分泌物的病症。
Br J Vener Dis. 1977 Oct;53(5):314-23. doi: 10.1136/sti.53.5.314.
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Comparison of ornidazole and tinidazole in single-dose treatment of trichomoniasis in women.奥硝唑与替硝唑单剂量治疗女性滴虫病的比较。
Br J Vener Dis. 1977 Jun;53(3):193-4. doi: 10.1136/sti.53.3.193.
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Metronidazole-resistant Trichomonas vaginalis.甲硝唑耐药阴道毛滴虫
Br J Vener Dis. 1979 Oct;55(5):351-3. doi: 10.1136/sti.55.5.351.
本文引用的文献
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Trichomonal vaginitis treated with one dose of metronidazole.单剂量甲硝唑治疗滴虫性阴道炎。
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2
Treatment of trichomoniasis in the female with a single dose of tinidazole.女性滴虫病单次服用替硝唑治疗。
S Afr Med J. 1973 Jul 21;47(28):1222-4.
3
Tetracyclines and host-defense mechanisms.四环素与宿主防御机制。
Antimicrob Agents Chemother. 1973 Jun;3(6):711-5. doi: 10.1128/AAC.3.6.711.
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Treatment of trichomonal vaginitis with a single oral dose of metronidazole.单次口服甲硝唑治疗滴虫性阴道炎
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Br J Vener Dis. 1974 Apr;50(2):148-50. doi: 10.1136/sti.50.2.148.
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Sexually-transmitted diseases in women.女性性传播疾病
Br J Vener Dis. 1974 Jun;50(3):217-21. doi: 10.1136/sti.50.3.217.
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A clinical pattern for making an immediate-presumptive diagnosis of gonococcal infection in women.
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