Forsgren A, Grarpe H
Antimicrob Agents Chemother. 1973 Jun;3(6):711-5. doi: 10.1128/AAC.3.6.711.
The effects of different tetracyclines on the bactericidal action of serum and on phagocytosis and intracellular killing of bacteria were investigated. Opsonization, phagocytosis, and intracellular killing were not significantly affected by any of the investigated tetracyclines. The bactericidal action of serum on Escherichia coli was substantially reduced by all tetracyclines investigated. In this respect, doxycycline had a much more pronounced action than the other tetracyclines. The serum bactericidal effect could be completely restored by addition of Mg(2+).
研究了不同四环素对血清杀菌作用以及对细菌吞噬作用和细胞内杀灭的影响。所研究的任何一种四环素对调理作用、吞噬作用和细胞内杀灭均无显著影响。所研究的所有四环素均使血清对大肠杆菌的杀菌作用大幅降低。在这方面，多西环素的作用比其他四环素更为显著。添加Mg(2+)可使血清杀菌作用完全恢复。
