Liu Hao, Ding Aijia, Aloke Goet, Mvogo Ndzana Louis B, Wan Miao, Lin Yujing, Zhang Jianglin
Department of Dermatology, Xiangya Hospital of Central South University, Changsha 410005, China.
Department of Dermatology, Xiangya Hospital of Central South University, Changsha 410005, China.
Photodiagnosis Photodyn Ther. 2020 Jun;30:101660. doi: 10.1016/j.pdpdt.2020.101660. Epub 2020 Feb 25.
Perifolliculitis capitis abscedens et suffodiens (PCAS), also known as dissecting cellulitis of the scalp (DCS), is a rare, chronic, suppurative inflammatory disease of the scalp which may evolve into cicatricial alopecia. Its refractory nature has a detrimental impact on patients' quality of life. Here, we report five cases of PCAS treated with 5% 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT), prior to which different methods of surgical intervention were given. The surgical interventions were under local anesthesia. In general, all surgical interventions, pretreatments and PDT were well tolerated. 4 patients showed complete clearance of lesions and 1 patient attained significant improvement of symptoms 1 month after treatment. This suggested that surgical interventions, combined with topical ALA-PDT could be an effective, minimally-invasive, and safe alternative for PCAS, especially for cases recalcitrant to other conventional therapies.
穿掘性蜂窝织炎型头皮毛囊周围炎（PCAS），也称为头皮深部蜂窝织炎（DCS），是一种罕见的、慢性的、化脓性头皮炎症性疾病，可能会发展为瘢痕性脱发。其难治性对患者的生活质量有不利影响。在此，我们报告5例采用5%氨基酮戊酸光动力疗法（ALA-PDT）治疗的PCAS病例，在此之前采用了不同的手术干预方法。手术干预在局部麻醉下进行。总体而言，所有手术干预、预处理和光动力疗法耐受性良好。4例患者病变完全清除，1例患者在治疗1个月后症状明显改善。这表明手术干预联合外用ALA-PDT可能是PCAS的一种有效、微创且安全的替代治疗方法，尤其适用于对其他传统疗法耐药的病例。
