Su Yanqian, Xu Qingqing, Zhang Chunmin, Zhang Chunhong
Department of Dermato-venereology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.
Department of Dermato-venereology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.
Photodiagnosis Photodyn Ther. 2021 Mar;33:102103. doi: 10.1016/j.pdpdt.2020.102103. Epub 2020 Dec 20.
Perifolliculitis capitis abscedens et suffodiens (PCAS) is a rare chronic inflammatory dermatosis of the scalp, which is a refractory and recrudescent disease. Symptoms of PCAS include follicular papules, suppurative nodules, cysts, sinuses, fistulas, and these usually evolve into patchy alopecia or cicatricial alopecia, which seriously affects the beauty and quality of life of patients. In this paper, we report 3 cases of PCAS each of whom received 5% 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) combined with isotretinoin. Fire needle intervention was used as a pretreatment for ALA-PDT. All pretreatments and ALA-PDT were well tolerated. All patients showed complete clearance of skin lesions and 1 patient attained significant improvement of symptoms after 1 month of treatment. No patients had recurrence with minimum one year follow up. This suggests that topical ALA-PDT pre-treated by fire needle combined with oral isotretinoin could be an eff ;ective, non-invasive, safe method with low recurrence for PCAS.
穿掘性蜂窝状头皮炎（PCAS）是一种罕见的头皮慢性炎症性皮肤病，是一种难治且易复发的疾病。PCAS的症状包括毛囊丘疹、化脓性结节、囊肿、窦道、瘘管，这些通常会演变成斑片状脱发或瘢痕性脱发，严重影响患者的美观和生活质量。在本文中，我们报告了3例PCAS患者，他们均接受了基于5%氨基酮戊酸的光动力疗法（ALA-PDT）联合异维A酸治疗。火针干预被用作ALA-PDT的预处理。所有预处理和ALA-PDT均耐受性良好。所有患者的皮肤病变均完全清除，1例患者在治疗1个月后症状明显改善。在至少1年的随访中，无患者复发。这表明火针预处理联合口服异维A酸的局部ALA-PDT可能是一种治疗PCAS的有效、无创、安全且复发率低的方法。
