Yilmaz Nesrin Helvaci, Saricaoğlu Mevhibe, Eser Hale Yapici, Düz Özge Arici, Polat Burcu, Özer Fahriye Feriha
Department of Neurology, İstanbul Medipol University Faculty of Medicine, İstanbul, Turkey.
Department of Neuroscience, İstanbul Medipol University Faculty of Medicine, İstanbul, Turkey.
Noro Psikiyatr Ars. 2019 Nov 25;57(1):56-60. doi: 10.29399/npa.24716. eCollection 2020 Mar.
To investigate the relationship between pain, freezing of gait (FOG) and falls in Parkinson's Disease (PD).
The study included 110 PD patients. The Unified PD Rating Scale (UPDRS) and Hoehn and Yahr Scale were used to evaluate disease severity. The patients self-reported occurrence of FOG and falls, and the FOG Questionnaire was administered to evaluate the severity of FOG. A visual analog scale (VAS) was used to measure the severity of pain and pain localization was self-reported by the patients.
Fifty-eight of the patients had FOG and 43 experienced falls. Among the patients, 42 had no pain, whereas 35 had lower extremity pain. Higher UPDRS motor and FOG scores, and advanced-stage disease were noted in significantly more of the patients with FOG and falls. VAS scores were not affected by the presence of FOG or falls. There was a positive correlation between the severity of FOG and VAS score in the male patients (r=0.308; p=0.010). More patients with falls had lower extremity pain than those without falls (r=0.308; p=0.010).
Patients with FOG and falls had more severe motor findings. Pain is correlated with both FOG and falls. Further investigations should be done to understand the mechanism of this relationship to prevent the motor complications in advanced PD.
研究帕金森病（PD）中疼痛、冻结步态（FOG）与跌倒之间的关系。
该研究纳入了110例PD患者。采用统一帕金森病评定量表（UPDRS）和 Hoehn 及 Yahr 量表评估疾病严重程度。患者自行报告FOG和跌倒的发生情况，并使用FOG问卷评估FOG的严重程度。采用视觉模拟量表（VAS）测量疼痛严重程度，患者自行报告疼痛部位。
58例患者有FOG，43例经历过跌倒。患者中，42例无疼痛，35例有下肢疼痛。FOG和跌倒患者中，更高的UPDRS运动评分和FOG评分以及疾病晚期更为常见。VAS评分不受FOG或跌倒的影响。男性患者中，FOG严重程度与VAS评分呈正相关（r=0.308；p=0.010）。跌倒患者中下肢疼痛的比例高于未跌倒患者（r=0.308；p=0.010）。
有FOG和跌倒的患者有更严重的运动表现。疼痛与FOG和跌倒均相关。应进一步开展研究以了解这种关系的机制，从而预防晚期PD的运动并发症。
